Results 111 to 120 of about 1,292,062 (304)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Five ways to model active processes in elastic solids: Active forces, active stresses, active strains, active fibers, and active metrics [PDF]
Mechanics Research Communications, 2018 An important contribution of Gerard Maugin was his study of anelasticity. It is well appreciated that in biological systems, anelasticity manifests itself through growth and remodeling and Maugin and his collaborators have helped build a general theory suitable to model such fundamental processes.
openaire +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Functional appliances: Which one, When? Part 1 — Rationale for selection
Australasian Orthodontic Journal, 1985 One current question is whether functional appliance therapy is capable of producing clinically significant changes in the human dento-facial complex under realistic treatment conditions.
Roberts Graeme L.
doaj +1 more source
Analyzing critical propagation in a reaction-diffusion-advection model using unstable slow waves
, 2014 The effect of advection on the critical minimal speed of traveling waves is studied. Previous theoretical studies estimated the effect on the velocity of stable fast waves and predicted the existence of a critical advection strength below which ...
Dahlem, Markus A. +2 more
core +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Maxillary control with functional appliances: some clinical observations
Australasian Orthodontic Journal, 1985 Accepting that the activator appliance can be used successfully to correct the occlusion by modifying the relationship of the dentitions and modifying growth characteristics of maxilla and mandible, what are the limitations of the appliance in the ...
Heath John R.
doaj +1 more source
Turing structures in dc gas discharges
, 2005 Self-organized spatial plasma structures exhibit many similarities with Turing structures obtained in biology and chemistry. Using an analytical mesoscopic approach it is shown that plasma balls of fire belong to the same class of Turing structures like ...
Popescu, S.
core +1 more source