Results 31 to 40 of about 5,159,180 (362)

Active colloidal molecules in activity gradients [PDF]

Physical Review E, 2022
We consider a rigid assembly of two active Brownian particles, forming an active colloidal dimer, in a gradient of activity. We show analytically that depending on the relative orientation of the two particles the active dimer accumulates in regions of either high or low activity, corresponding to, respectively, chemotaxis and antichemotaxis.
Hidde D. Vuijk, Sophie Klempahn, Holger Merlitz, Jens-Uwe Sommer, Abhinav Sharma   +4 more
openaire   +3 more sources

Active learning enabled activity recognition [PDF]

Pervasive and Mobile Computing, 2016
© 2016 IEEE, 2016 IEEE International Conference on Pervasive Computing and Communications (PerCom)
Hossain, H M Sajjad, Roy, Nirmalya, Khan, Md Abdullah Al Hafiz   +2 more
openaire   +1 more source

ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types

Nature Communications, 2016
Early dissemination, metastasis and therapy resistance are central hallmarks of aggressive cancer types and the leading cause of cancer-associated deaths.
Waltraut Lehmann, Dirk Mossmann, J. Kleemann, Kerstin Mock, C. Meisinger, T. Brummer, Ricarda Herr, S. Brabletz, Marc P. Stemmler, T. Brabletz   +9 more
semanticscholar   +1 more source

The Double-Edged Sword of SIRT3 in Cancer and Its Therapeutic Applications

Frontiers in Pharmacology, 2022
Reprogramming of cellular energy metabolism is considered an emerging feature of cancer. Mitochondrial metabolism plays a crucial role in cancer cell proliferation, survival, and metastasis.
Shumin Ouyang, Qiyi Zhang, Linlin Lou, Kai Zhu, Zeyu Li, Peiqing Liu, Xiaolei Zhang   +6 more
doaj   +1 more source

Activate, Inactive, Activity. [PDF]

, 2021
<p>Sports facilities in the Central Wellington area cater to physical activity for only a select portion of the population. Most of the time use is determined by the posts at each end of the field. Through the process of design research, I will test ways of maximizing space which is not used in thesefacilities to bring more physical and ...
openaire   +1 more source

Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer

Frontiers in Pharmacology, 2021
Fibroblast growth factor receptor 4 (FGFR4) is a tyrosine kinase receptor that is a member of the fibroblast growth factor receptor family and is stimulated by highly regulated ligand binding.
Yanan Liu, Yanan Liu, Canwei Wang, Jifa Li, Jiandong Zhu, Chengguang Zhao, Chengguang Zhao, Huanhai Xu   +7 more
doaj   +1 more source

The Role and Therapeutic Perspectives of Sirtuin 3 in Cancer Metabolism Reprogramming, Metastasis, and Chemoresistance

Frontiers in Oncology, 2022
Sirtuin 3 (SIRT3), the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, acts as a metabolic modulator mainly located in mitochondria via regulating the process of the relevant biochemical processes by targeting crucial mediators. Recently,
QingYi Zhao, Jing Zhou, Feng Li, Sen Guo, Liang Zhang, Jing Li, Qin Qi, Qin Qi, Yin Shi, Yin Shi   +9 more
doaj   +1 more source

Probing Structure and Function of Alkali Sensor IRR with Monoclonal Antibodies

Biomolecules, 2020
To study the structure and function of the pH-regulated receptor tyrosine kinase insulin receptor-related receptor (IRR), а member of the insulin receptor family, we obtained six mouse monoclonal antibodies against the recombinant IRR ectodomain.
Alexander S. Goryashchenko, Andrey A. Mozhaev, Oxana V. Serova, Tatiana N. Erokhina, Alexander N. Orsa, Igor E. Deyev, Alexander G. Petrenko   +6 more
doaj   +1 more source

A Novel Mechanism for SIRT1 Activators That Does Not Rely on the Chemical Moiety Immediately C-Terminal to the Acetyl-Lysine of the Substrate

Molecules, 2022
SIRT1, an NAD+-dependent deacetylase, catalyzes the deacetylation of proteins coupled with the breakdown of NAD+ into nicotinamide and 2′-O-acetyl-ADP-ribose (OAADPr).
Nian-Da Yu, Bing Wang, Xin-Zhu Li, Hao-Zhen Han, Dongxiang Liu   +4 more
doaj   +1 more source

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source