Results 161 to 170 of about 3,917,874 (426)

Developmental Role and Regulation of cortex, a Meiosis-Specific Anaphase-Promoting Complex/Cyclosome Activator

PLoS Genetics, 2007
During oogenesis in metazoans, the meiotic divisions must be coordinated with development of the oocyte to ensure successful fertilization and subsequent embryogenesis.
Jillian A Pesin, T. Orr-Weaver
semanticscholar   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

The urokinase-type plasminogen activator polymorphism PLAU_1 is a risk factor for APOE-ε4 non-carriers in the Italian Alzheimer’s disease population and does not affect the plasma Aβ(1–42) level

Neurobiology of Disease, 2007
Sporadic Alzheimer’s disease (AD) is the most frequent form of dementia in the elderly. A non-conservative polymorphism in the urokinase-type plasminogen activator gene (PLAU_1=RS2227564) has been analyzed, but data are conflicting on whether it is a ...
Marzia Pesaresi, Sara Batelli, Francesca Prato, Letizia Polito, Carlo Lovati, Elio Scarpini, Pierluigi Quadri, Claudio Mariani, Diego Albani, Gianluigi Forloni   +9 more
doaj  

Identification of survival motor neuron as a transcriptional activator-binding protein.

Human Molecular Genetics, 1999
Spinal muscular atrophy (SMA) is an inherited neuro-muscular disease characterized by specific degeneration of spinal cord anterior horn cells and subsequent muscle atrophy.
John Strasswimmer, C. Lorson, D. Breiding, Jason J. Chen, T. Le, A. Burghes, E. Androphy   +6 more
semanticscholar   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

LncRNA SRA1 may play a role in the uterine leiomyoma tumor growth regarding the MED12 mutation pattern

International Journal of Women's Health, 2019
Mojdeh Akbari,1 Fakhrolmolouk Yassaee,2 Mona Aminbeidokhti,1 Atieh Abedin-Do,1,3 Reza Mirfakhraie1,41Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Obstetrics and ...
Akbari M, Yassaee F, Aminbeidokhti M, Abedin-Do A, Mirfakhraie R   +4 more
doaj  

The yeast three-hybrid system as an experimental platform to identify proteins interacting with small signaling molecules in plant cells: Potential and limitations

Frontiers in Plant Science, 2011
Chemical genetics is a powerful scientific strategy that utilizes small bioactive molecules as experimental tools to unravel biological processes. Bioactive compounds occurring in nature represent an enormous diversity of structures that can be used to ...
Stéphanie eCottier, Timon eMönig, Zheming eWang, Jiří eSvoboda, Wilhelm eBoland, Markus eKaiser, Erich eKombrink   +6 more
doaj   +1 more source

Proteins of the lectin pathway of the complement system activation: immunobiological functions, genetics and involvement in the pathogenesis of human diseases

, 2022
M. V. Smolnikova, Sergey Tereshchenko
openalex   +2 more sources

Dual and opposing roles of primary cilia in medulloblastoma development. [PDF]

, 2009
Recent work has shown that primary cilia are essential for Hedgehog (Hh) signaling during mammalian development. It is also known that aberrant Hh signaling can lead to cancer, but the role of primary cilia in oncogenesis is not known. Cerebellar granule
Alvarez-Buylla, Arturo, Dlugosz, Andrzej A, Ellison, David W, Gilbertson, Richard J, Han, Young-Goo, Kim, Hong Joo   +5 more
core  

Hidden long evolutionary memory in a model biochemical network

, 2017
We introduce a minimal model for the evolution of functional protein-interaction networks using a sequence-based mutational algorithm, and apply the model to study neutral drift in networks that yield oscillatory dynamics. Starting with a functional core
Ali, Md. Zulfikar, Mukhopadhyay, Ranjan, Wingreen, Ned S.   +2 more
core   +1 more source