Results 161 to 170 of about 262,173 (350)
Autism: genetics, environmental stressors, maternal immune activation, and the male bias in autism [PDF]
, 2022 Sarah Otaru, David A. Lawrence
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Evidence for single nucleotide polymorphisms and their association with bipolar disorder
Neuropsychiatric Disease and Treatment, 2013 Aleksandra Szczepankiewicz1,21Laboratory of Molecular and Cell Biology, 2Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, PolandAbstract: Bipolar disorder (BD) is a complex disorder with a number of susceptibility genes ...
Szczepankiewicz A
doaj
Genetics reveals importance of platelet activating factor in asthma and possibly other inflammatory states. [PDF]
, 1996 Jay A. Nadel
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C82 CARDIOMYOPATHIES AND GENETICS: ACTIVATION OF A SHARED PATH. INSIGHTS FROM CUNEO HOSPITAL [PDF]
, 2023 L Coppini, G Coletta, Roberta Rossini
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Genetic toxicology and genetically active environmental factors
International Journal of Biology and Chemistry, 2018 R. Islamov, A. Aitynova, A. Zhussupova
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source