Results 181 to 190 of about 260,779 (356)

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Expression analysis of protein inhibitor of activated STAT (PIAS) genes in IFNβ-treated multiple sclerosis patients

Journal of Inflammation Research, 2018
Mohammad Taheri,1,* Ghazaleh Azimi,2,* Arezou Sayad,2 Mehrdokht Mazdeh,3 Shahram Arsang-Jang,4,5 Mir Davood Omrani,5 Soudeh Ghafori-Fard2 1Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Medical ...
Taheri M, Azimi G, Sayad A, Mazdeh M, Arsang-Jang S, Omrani MD, Ghafouri-Fard S   +6 more
doaj  

Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform†

, 2017
Kirk J. Wangensteen, Yue J. Wang, Zhixun Dou, Amber W. Wang, Elham Mosleh‐Shirazi, Max A. Horlbeck, Luke A. Gilbert, Jonathan S. Weissman, Shelley L. Berger, Klaus H. Kaestner   +9 more
openalex   +1 more source

Peroxisome Proliferator-Activated Receptor-δ Genotype Influences Metabolic Phenotype and May Influence Lipid Response to Statin Therapy in Humans: A Genetics of Diabetes Audit and Research Tayside Study [PDF]

, 2010
Lindsay Burch, Louise A. Donnelly, Alex S. F. Doney, Jeffrey D. Brady, Anna Tommasi, Adrian L. Whitley, Catharine A. Goddard, Andrew D. Morris, Michael K. Hansen, Nicholette D. Palmer   +9 more
openalex   +1 more source

Genetic toxicology and genetically active environmental factors

International Journal of Biology and Chemistry, 2018
A. I. Zhussupova, Rinat Islamov, A. Aitynova   +2 more
openaire   +2 more sources

Objectives and activities of the Genetic Alliance [PDF]

American Journal of Public Health, 2000
M E Davidson, J Weiss
openaire   +2 more sources

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Genetic evidence informs the direction of therapeutic modulation in drug development. [PDF]

NPJ Drug Discov
Chen R, Duffy Á, Park JK, Stein D, Schlessinger A, Itan Y, Glicksberg BS, Tinker RJ, Jordan DM, Rocheleau G, Do R.   +10 more
europepmc   +1 more source

The Relationship between Peroxisome Proliferator-Activated Receptor-γ and Renin: A Human Genetics Study [PDF]

, 2010
Patricia Underwood, Bei Sun, Jonathan S. Williams, Luminita H. Pojoga, Bindu Chamarthi, Jessica Lasky‐Su, Benjamin A. Raby, Paul N. Hopkins, Xavier Jeunemaı̂tre, Nancy J. Brown, Gail K. Adler, Gordon H. Williams   +11 more
openalex   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source