Results 181 to 190 of about 3,963,692 (395)

C82 CARDIOMYOPATHIES AND GENETICS: ACTIVATION OF A SHARED PATH. INSIGHTS FROM CUNEO HOSPITAL [PDF]

, 2023
L Coppini, G Coletta, Roberta Rossini
openalex   +1 more source

Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing

Nature Genetics, 2013
D. Robinson, Yi-Mi Wu, Shanker Kalyana-Sundaram, Xuhong Cao, R. Lonigro, Yun‐Shao Sung, Chun‐Liang Chen, Lei Zhang, Rui Wang, Fengyun Su, M. Iyer, S. Roychowdhury, J. Siddiqui, K. Pienta, L. Kunju, M. Talpaz, J. Mosquera, S. Singer, S. Schuetze, C. Antonescu, A. Chinnaiyan   +20 more
semanticscholar   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Increased activation of the WNT pathway in brain tissue from patients with cortical dysplasia type IIb: genetics and functional aspects [PDF]

Fábio Jean Varella, Fernando Antônio Costa Xavier, Gabriele Zanirati, João Ismael Budelon Gonçalves, Thales Thor Ramos Previato, Douglas Bottega Pazzin, Normando G Pereira-Neto, Eliseu Paglioli, William Alves Martins, André Palmini, Adriana Souza dos Santos, José G. Abreu, Kamila Souto Leichtweis, Denise Cantarelli Machado, Jaderson Costa da Costa, Daniel Rodrigo Marinowic   +15 more
openalex   +1 more source

Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis via SYK activation [PDF]

, 2019
Tom van der Wel, Riet Hilhorst, Hans den Dulk, Tim van den Hooven, Nienke Prins, Joost A. P. M. Wijnakker, Bogdan I. Florea, Eelke B. Lenselink, Gerard J. P. van Westen, Rob Ruijtenbeek, Herman S. Overkleeft, Allard Kaptein, Tjeerd Barf, Mario van der Stelt   +13 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Efficient Targeted Mutagenesis in Medaka Using Custom-Designed Transcription Activator-Like Effector Nucleases

Genetics, 2013
Satoshi Ansai, Tetsushi Sakuma, Takashi Yamamoto, H. Ariga, N. Uemura, R. Takahashi, M. Kinoshita   +6 more
semanticscholar   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source