Results 291 to 300 of about 260,779 (356)

Establishment and optimization of the two‐step induction system for generating primordial germ cell‐like cells from chicken embryonic stem cells

FEBS Open Bio, EarlyView.
This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li, XianShuai Xu, GuangZheng Liu, XiaoQian Lv, JiuZhou Song, HongYan Sun, YingJie Niu, QiSheng Zuo, Wei Han, BiChun Li, Kai Jin   +10 more
wiley   +1 more source

Case Report: The nonsense variation of the cardiac transcription factor <i>NKX2-5</i> has been identified in a Chinese family with nonsyndromic congenital heart disease. [PDF]

Front Genet
Zhang H, Chen J, Wang H, Xiang Q, Liu S.
europepmc   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Genome-wide RNAi screening in C. elegans reveals OXPHOS and pyrimidine synthesis pathways as PKA regulators. [PDF]

Commun Biol
Li Y, Duan D, Zhu S, Liu Z, Zhang Q, Wu L.   +5 more
europepmc   +1 more source

acmgscaler: an R package and Colab for standardized gene-level variant effect score calibration within the ACMG/AMP framework. [PDF]

Bioinformatics
Badonyi M, Marsh JA.
europepmc   +1 more source

Cross-species rescue reveals sequence requirements for a rapidly evolving intrinsically disordered region. [PDF]

PLoS Biol
Park SO, Khondker R, Blank A, Dyatel A, Frazer C, Bennett RJ, Reid RJD, Rothstein R, Berchowitz LE.   +8 more
europepmc   +1 more source

The importance of imperfect pre-clinical models in adolescent idiopathic scoliosis.

Dis Model Mech
Sepich DS, Gray RS, Ahituv N, Gurnett CA, Rios JJ, Solnica-Krezel L, Wise CA.   +6 more
europepmc   +1 more source