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Mechanism of MEK1 phosphorylation by the N-terminal acidic motif-mediated asymmetric BRAF dimer
Kondo Y +7 more
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The Genetics of Physical Activity
Current Cardiology Reports, 2017Physical activity (PA) is a well-established modifiable lifestyle determinant for multiple cardio-metabolic outcomes. While many psychosocial and environmental correlates of PA have been identified, current understanding of the genetic architecture that contributes to PA is still very limited, especially when compared to other phenotypes such as ...
Simin Liu +5 more
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Electronmicroscopy of Genetic Activity
Annual Review of Biochemistry, 1973ACTIVE GENES FROM AMPHIBIAN OOCYTES 379 Ribosomal RNA genes 380 Lampbrush chromosomes 383 ACTtVZ GeNeS FROM BACteRiA 384 Structural genes 384 Ribosomal RNA genes 388 Bacteriophage genetic activity 390 YEAST GENETIC ACTiViTY 392 MAMMALIAN GE ETIC ACTIVITY ...
O L Miller, B A Hamkalo
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Genetic prodrug activation therapy
The Lancet, 1997Genetic prodrug activation therapy shows promise as a therapeutic option for the treatment of cancer as well as a variety of other diseases. It involves the insertion of a gene encoding a drug-metabolizing enzyme into cells and the systemic administration of a prodrug. The prodrug is converted to a cytotoxic agent by the action of the expressed enzyme.
H. S. Pandha +4 more
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The genetics of macrophage activation syndrome
Genes & Immunity, 2020Macrophage activation syndrome (MAS), or secondary hemophagocytic lymphohistiocytosis (HLH), is a cytokine storm syndrome associated with multi-organ system dysfunction and high mortality rates. Laboratory and clinical features resemble primary HLH, which arises in infancy (1 in 50,000 live births) from homozygous mutations in various genes critical to
Randy Q. Cron, Grant S. Schulert
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Genetic activity of allyl chloride
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1978Allyl chloride (3-chloroprene) is mutagenic for Salmonella typhimurium and it induces gene conversions in Saccharomyces cerevisiae. It also displays DNA-modifying activity for E. coli. This is in contrast to a recent study which reported its lack of genetic activity for Salmonella typhimurium.
Herbert S. Rosenkranz +2 more
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Genetic activity of niridazole in yeast
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1975Niridazole, one of several drugs presently known to be of value in the treatment of human schistosomiasis, was tested for its activity in inducing mitotic recombination in yeast. It was found that niridazole is genetically active when the treatment of yeast cells is performed in a rich medium (YPG-medium) under growing conditions, but not when ...
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Genetic Factors in Activity Motivation
Child Development, 1966A study of 61 pairs of identical (MZ) and fraternal (DZ) grade-school twin girls found moderate genetic contributions to individual differences in several aspects of activity motivation: reaction time, variety of activity, anxiety, and impatience. Activity motivation was defined by empirical clusters of related measures including ratings, experimental ...
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