Results 311 to 320 of about 260,779 (356)
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Genetic and Non-Genetic Determinants of the Pharmacological Activity of Statins
Current Drug Metabolism, 2016Statins are cholesterol-lowering agents which belong to the group of the most commonly prescribed drugs. The use of statins has become the standard treatment in patients with an increased risk of cardiovascular and coronary heart diseases. However, many clinical studies have shown that 13 - 75% of patients fail to achieve LDL-cholesterol and total ...
Jakub Mikolajewski +3 more
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Activities of the National Institute of Genetics
Nature, 1972Active research involving many different aspects of genetics has led to exciting discoveries at the National Institute of Genetics.
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Genetic Vaccination for the Active Immunotherapy of Cancer
Current Gene Therapy, 2001Molecular biology techniques have given novel impetus to the immunotherapy of cancer because they have catalyzed the identification of several potential tumor antigens, and permitted the generation of vectors for the delivery of genetic material encoding these antigens.
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Genetic activity of vinylidene chloride in yeast
Mutation Research/Genetic Toxicology, 1981Vinylidene chloride (VDC) was tested for its ability to induce both point mutation and mitotic gene conversion in a diploid strain (D7) of the yeast Saccharomyces cerevisiae in a suspension test with and without a mammalian microsomal activation system, and in the intrasanguineous host-mediated assay in mice. In suspension tests with D7, VCD was toxic
Carlo Bauer +5 more
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Genetic epidemiology of induced CYP3A4 activity
Pharmacogenetics and Genomics, 2011The cytochrome P450 3A4 (CYP3A4) enzyme is implicated in the metabolism of more than 50% of all prescribed medications and its activity - including induced or inhibited activity - is deemed to be a crucial determinant of interindividual variability in drug disposition, poor therapeutic efficacy, and adverse response to medication.We used the classical ...
Rahmioglu, Nilufer +10 more
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Genetically encoded neural activity indicators
Current Opinion in Neurobiology, 2012Recording activity from identified populations of neurons is a central goal of neuroscience. Changes in membrane depolarization, particularly action potentials, are the most important features of neural physiology to extract, although ions, neurotransmitters, neuromodulators, second messengers, and the activation state of specific proteins are also ...
Loren L. Looger, Oliver Griesbeck
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Genetic activity profiles of anticancer drugs
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1996The results from short-term tests for genetic and related effects, abstracted from the open literature for 36 anticancer drugs, are examined in this review. Data for 27 of these agents are available in the EPA/IARC Genetic Activity Profile (GAP) database.
H.F. Stack +2 more
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Genetical Aspects of Active Defence [PDF]
, 1982 I find myself in a rather uncomfortable position in presenting this paper. The reason for this is that what I have to say does not support much of the speculation and dogma that has been presented in preceding papers. I feel like a non-believer in a congregation of believers.
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Chromatin dynamics and the modulation of genetic activity
Trends in Biochemical Sciences, 1992Chromatin, the genetic material of eukaryotes, is a dynamic macromolecular assembly that continuously changes its composition and conformation to accommodate different stages of genetic activity, e.g. transcription and replication. Evidence is accumulating that the dynamic behavior of chromatin has important functional roles in the modulation of ...
Juan Ausió, Jeffrey C. Hansen
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Genetic differences in locomotor activation in mice
Pharmacology Biochemistry and Behavior, 1986Two highly inbred strains of mice were found to differ in habituation of activity repeatedly assessed in a toggle-box exploration task. The recombinant inbred (RI) strains derived from their cross resembled either one or the other parent strain, suggesting that a single gene exerts a marked influence on this behavior.
John C. Crabbe, John C. Crabbe
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