A secretory kinase complex regulates extracellular protein phosphorylation. [PDF]
, 2015 Although numerous extracellular phosphoproteins have been identified, the protein kinases within the secretory pathway have only recently been discovered, and their regulation is virtually unexplored.
Cui, Jixin +5 more
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Novel Nucleotide Variations, Haplotypes Structure and Associations with Growth Related Traits of Goat AT Motif-Binding Factor () Gene [PDF]
Asian-Australasian Journal of Animal Sciences, 2015 The AT motif-binding factor (ATBF1) not only interacts with protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) to suppress STAT3 signaling regulating embryo early development and cell differentiation, but is
Xiaoyan Zhang +7 more
doaj +1 more source
Genetic strategies to access activated neurons [PDF]
Current Opinion in Neurobiology, 2017 A major goal of modern neuroscience is to understand how ensembles of neurons participate in neural circuits underlying behavior. The recent explosion of genetically-encoded circuit analysis tools has allowed neuroscientists to characterize molecularly-defined neuronal types with unprecedented detail.
Laura, DeNardo, Liqun, Luo
openaire +2 more sources
Gene-Drug Interaction in Stroke
Stroke Research and Treatment, 2011 Stroke is the third cause of mortality and one of most frequent causes of long-term neurological disability, as well as a complex disease that results from the interaction of environmental and genetic factors.
Serena Amici +3 more
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Identification and functional study of GATA4 gene regulatory variants in type 2 diabetes mellitus
BMC Endocrine Disorders, 2021 Background Type 2 diabetes mellitus (T2D) is a common and complex disease. Dysfunction of pancreatic β cells, which cannot release sufficient insulin, plays a central role in T2D. Genetics plays a critical role in T2D etiology. Transcription factor GATA4
Liangcai Ding +6 more
doaj +1 more source
Genetically encoded indicators of neuronal activity [PDF]
Nature Neuroscience, 2016 Experimental efforts to understand how the brain represents, stores and processes information require high-fidelity recordings of multiple different forms of neural activity within functional circuits. Thus, creating improved technologies for large-scale recordings of neural activity in the live brain is a crucial goal in neuroscience.
Michael Z, Lin, Mark J, Schnitzer
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Reaction diffusion processes on random and scale-free networks [PDF]
, 2004 We study the discrete Gierer-Meinhardt model of reaction-diffusion on three different types of networks: regular, random and scale-free. The model dynamics lead to the formation of stationary Turing patterns in the steady state in certain parameter ...
De Wit A. +4 more
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The yeast PUF protein Puf5 has Pop2-independent roles in response to DNA replication stress. [PDF]
PLoS ONE, 2010 PUFs are RNA binding proteins that promote mRNA deadenylation and decay and inhibit translation. Yeast Puf5 is the prototype for studying PUF-dependent gene repression.
Ana Traven +3 more
doaj +1 more source
Transcriptional regulation of the ABCC6 gene and the background of impaired function of missense disease-causing mutations. [PDF]
, 2013 The human ATP-binding cassette family C member 6 (ABCC6) gene encodes an ABC transporter protein expressed primarily in the liver and to a lesser extent in the kidneys and the intestines.
Arányi, Tamás +5 more
core +1 more source
Generation and characterization of keap1a- and keap1b-knockout zebrafish
Redox Biology, 2020 The Keap1–Nrf2 pathway is an evolutionarily conserved mechanism that protects cells from oxidative stress and electrophiles. Under homeostatic conditions, Keap1 interacts with Nrf2 and leads to its rapid proteasomal degradation, but when cells are ...
Vu Thanh Nguyen +6 more
doaj +1 more source