Results 21 to 30 of about 4,610,135 (394)

Identification and characterization of a Mef2 transcriptional activator in schistosome parasites. [PDF]

PLoS Neglected Tropical Diseases, 2012
Myocyte enhancer factor 2 protein (Mef2) is an evolutionarily conserved activator of transcription that is critical to induce and control complex processes in myogenesis and neurogenesis in vertebrates and insects, and osteogenesis in vertebrates.
John N Milligan, Emmitt R Jolly
doaj   +1 more source

Effects of cell cycle noise on excitable gene circuits [PDF]

, 2016
We assess the impact of cell cycle noise on gene circuit dynamics. For bistable genetic switches and excitable circuits, we find that transitions between metastable states most likely occur just after cell division and that this concentration effect ...
Bennett, Matthew R., Gupta, Chinmaya, Josić, Krešimir, Ott, William, Veliz-Cuba, Alan   +4 more
core   +3 more sources

The Cryptococcus neoformans Alkaline Response Pathway: Identification of a Novel Rim Pathway Activator

PLoS Genetics, 2015
The Rim101/PacC transcription factor acts in a fungal-specific signaling pathway responsible for sensing extracellular pH signals. First characterized in ascomycete fungi such as Aspergillus nidulans and Saccharomyces cerevisiae, the Rim/Pal pathway ...
Kyla S. Ost, T. O. O 'meara, Naureen Huda, Shannon K Esher, J. Alspaugh, Dana A. Davis   +5 more
semanticscholar   +1 more source

Genetic Dissection of Antibiotic Adjuvant Activity

mBio, 2022
One strategy to confront the antibiotic resistance crisis is through the development of adjuvant compounds that increase the efficacy of established drugs. A key step in the development of a natural product adjuvant as a drug is identifying the resistance process it undermines to enhance antibiotic activity.
J. Bailey, L. Gallagher, W. T. Barker, V. B. Hubble, J. Gasper, C. Melander, C. Manoil   +6 more
openaire   +3 more sources

The Overlapping and Distinct Roles of HAM Family Genes in Arabidopsis Shoot Meristems

Frontiers in Plant Science, 2020
In Arabidopsis shoot apical meristems (SAMs), a well-characterized regulatory loop between WUSCHEL (WUS) and CLAVATA3 (CLV3) maintains stem cell homeostasis by regulating the balance between cell proliferation and cell differentiation.
Han Han, Han Han, Yuan Geng, Yuan Geng, Lei Guo, Lei Guo, An Yan, An Yan, Elliot M. Meyerowitz, Elliot M. Meyerowitz, Xing Liu, Xing Liu, Yun Zhou, Yun Zhou   +13 more
doaj   +1 more source

Sexual Dimorphism in Osteoclasts

Cells, 2020
Osteoclasts are the principal mediators of bone resorption. They form through the fusion of mononuclear precursor cells under the principal influence of the cytokines macrophage colony stimulating factor (M-CSF, aka CSF-1) and receptor activator of NF-κB
Joseph Lorenzo
doaj   +1 more source

The role of Schizosaccharomyces pombe SUMO ligases in genome stability [PDF]

, 2007
SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear that understanding the mechanisms that regulate the process is ...
A. Skilton, al-Khodairy, Allshire, Allshire, Andrews, Apionishev, Branzei, Chakrabarti, Cheng, E.A. Outwin, Ekwall, F.-X. Ogi, F.Z. Watts, Grishchuk, Ho, Ho, Hoege, Hooker, J.C.-Y. Ho, Johnson, Kagey, Kahyo, L. Gardner, L.K. Boyd, M.A.M. Trickey, McDonald, Okubo, Pichler, Potts, Reindle, Sachdev, Schmidt, Sergeant, Shayeghi, Shin, Stelter, Strahl-Bolsinger, Tanaka, Taylor, Thon, Watts, Xhemalce, Xhemalce, Zhao, Zhao   +44 more
core   +2 more sources

Use of the Iron-Responsive RBT5 Promoter for Regulated Expression in Candida albicans

mSphere, 2022
Engineered conditional gene expression is used in appraisal of gene function and pathway relationships. For pathogens like the fungus Candida albicans, conditional expression systems are most useful if they are active in the infection environment and if ...
Yinhe Mao, Norma V. Solis, Anupam Sharma, Max V. Cravener, Scott G. Filler, Aaron P. Mitchell   +5 more
doaj   +1 more source

A model for selection of eyespots on butterfly wings [PDF]

, 2015
The development of eyespots on the wing surface of butterflies of the family Nympalidae is one of the most studied examples of biological pattern formation.However, little is known about the mechanism that determines the number and precise locations of ...
A Gierer, Anotida Madzvamuse, Chandrasekhar Venkataraman, CR Brunetti, DL Benson, H Meinhardt, H Meinhardt, HF Nijhout, HF Nijhout, HF Nijhout, J Raspopovic, J Schnakenberg, JD Murray, JL Aragon, JM Otaki, Jordi Garcia-Ojalvo, K Page, KL Prudic, M Stevens, O Lakkis, P Beldade, PM Brakefield, R Dillon, R Dilão, R Sheth, RA Barrio, RD Reed, SB Carroll, SB Carroll, T Sekimura, TM Evans, Toshio Sekimura, Y Shirota   +32 more
core   +4 more sources

Astonishing advances in mouse genetic tools for biomedical research

Swiss Medical Weekly, 2015
The humble house mouse has long been a workhorse model system in biomedical research. The technology for introducing site-specific genome modifications led to Nobel Prizes for its pioneers and opened a new era of mouse genetics.
Walker Scot Jackson, Lech Kaczmarczyk
doaj   +1 more source