Results 1 to 10 of about 4,610,135 (394)
Genetics of Plasminogen Activator Inhibitor-1 (PAI-1) in a Ghanaian Population. [PDF]
PLoS ONE, 2015 Plasminogen activator inhibitor 1 (PAI-1), a major modulator of the fibrinolytic system, is an important factor in cardiovascular disease (CVD) susceptibility and severity.
Marquitta J White +7 more
doaj +5 more sources
Mouse genetics: Catalogue and scissors [PDF]
BMB Reports, 2012 Phenotypic analysis of gene-specific knockout (KO) mice hasrevolutionized our understanding of in vivo gene functions. Asthe use of mouse embryonic stem (ES) cells is inevitable forconventional gene targeting, the generation of knockout miceremains a ...
Han-Woong Lee
doaj +2 more sources
Cells, 2022 This is a spectacular moment for genetics to evolve in genome editing, which encompasses the precise alteration of the cellular DNA sequences within various species. One of the most fascinating genome-editing technologies currently available is Clustered
Ali Nasrallah +4 more
doaj +1 more source
Regulation of transcription elongation in response to osmostress [PDF]
, 1967 Cells trigger massive changes in gene expression upon environmental fluctuations. The Hog1 stress-activated protein kinase (SAPK) is an important regulator of the transcriptional activation program that maximizes cell fitness when yeast cells are exposed
Begley, Victoria Sarah +7 more
core +11 more sources
Targeted mutagenesis in the malaria mosquito using TALE nucleases. [PDF]
PLoS ONE, 2013 Anopheles gambiae, the main mosquito vector of human malaria, is a challenging organism to manipulate genetically. As a consequence, reverse genetics studies in this disease vector have been largely limited to RNA interference experiments.
Andrea L Smidler +4 more
doaj +1 more source
Recent advances in genetically modified large-animal models of human diseases
BIO Integration, 2022 Large-animal models show greater advantages than rodents in recapitulating human genetic diseases, primarily because of their higher similarity to humans in terms of anatomy, physiology and genetics.
Jing Zhang, Xiaoyue Sun, Chunwei Cao
doaj +1 more source
Frontiers in Endocrinology, 2023 Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy/childhood and is a serious condition associated with severe recurrent attacks of hypoglycemia due to dysregulated insulin secretion.
Assmaa ElSheikh +2 more
doaj +1 more source
iScience, 2020 Summary: DNA double-strand break (DSB) repair is critical for cell survival and genome integrity. Upon recognition of DSBs, repair proteins are transiently upregulated to facilitate repair through homologous recombination (HR) or non-homologous end ...
Jake L. Owens +9 more
doaj +1 more source
About Epizootic Situation on Major Helminthosis of Different Breeds of Pigs in Georgia
Российский паразитологический журнал, 2020 The purpose of the research is to study the epizootic situation on major helminthosis of different breed groups of pigs in Georgia. Materials and methods.
L. M. Udzhmadzhuridze +3 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2020 Based on engineered or bacterial nucleases, the development of genome editing technologies has opened up the possibility of directly targeting and modifying genomic sequences in almost all eukaryotic cells.
Hongyi Li +5 more
semanticscholar +1 more source