Results 121 to 130 of about 783,140 (262)
Active case finding in tuberculosis: Need for a cautious approach
Journal of Global Infectious Diseases, 2020 openaire +3 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Abstract Background Tuberculosis (TB) remains a global health challenge. Recent studies have compared active case-finding (ACF) with passive case-finding (PCF) and various ACF strategies, assessing diagnostic yield, treatment outcomes, cost-effectiveness, and overall TB control impact.
Sonia Menon +2 more
openaire +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
High yield of retrospective active case finding for leprosy in Comoros
PLOS Neglected Tropical Diseases, 2022 Nimer Ortuño-Gutiérrez +11 more
openaire +5 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Active Case Finding in the Elderly Tuberculosis in South Korea [PDF]
Tuberculosis and Respiratory Diseases, 2019 openaire +2 more sources
"Active case-finding versus Passive case finding in Pulmonary Tuberculosis- Look before you leap?"
Case Series Active case-finding versus Passive case finding in Pulmonary Tuberculosis- Look before you leap? Tuberculosis (TB) is one among the major health problem in India. India has an estimated 3 million TB patients. The Indian government has set up a program called National Tuberculosis Elimination Program (NTEP) to eliminate TB by 2025.
Fasmi Navas, Ketaki Utpat, Unnati Desai
openaire +3 more sources