Results 131 to 140 of about 783,140 (262)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Diagnostic accuracy of TB-LAMP and smear microscopy for pulmonary TB in active case finding. [PDF]

IJTLD Open
Shimouchi A, Gopali RS, Maharjan B, Shrestha Y, Hirano Y, Shah NP, Ghimire P, Shrestha P, Okada K.   +8 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Factors associated with tuberculosis symptom reporting among persons deprived of liberty in Brazil during active case finding: a cross-sectional study. [PDF]

BMJ Public Health
Bampi JVB, Salindri AD, Gonçalves IB, Coene JS, Croda MG, da Silva AM, Jung E, Busatto C, de Oliveira RD, Cunha EAT, Andrews JR, Croda J.   +11 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Construction and Validation of Active Case-Finding Tool in Community Participants with Chronic Obstructive Pulmonary Disease Using an Interpretable Machine Learning Approach. [PDF]

Int J Chron Obstruct Pulmon Dis
Tian H, Wu F, Sun C, Deng Z, Zhou Y, Ran P.   +5 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Does active case finding detect TB early in programme settings? A national-level study in India. [PDF]

Public Health Action
Shewade HD, Kiran Pradeep S, Ravichandran P, Kiruthika G, Shah AN, Vadera B, Roddawar V, Mattoo SK, Iyer S, Tumu D, Chowdhury A, Devika S, Chadwick J, Vaidya RR, Singh P, Panda SK, Baig MA, Suma KV, Suleka M, Digal AK, Banerjee D, Prasanna ML, Waghela DY, Krishnaraj A, Kashyap P, Parmar JS, Mishra CK, Das S, Kumar A, Kumar A, Yadav S, Chetry S, Kumar A, Pathak M, Singh S, Tabrez S, Mehra P, Ramesh S, Bishnu B, Mahesh G, Rajesham A, Mishra BK, Chandra Tripathi U, Khayyam KU, Rade K, Rao R, Murhekar MV.   +46 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Active case finding for tuberculosis among Ukrainian soldiers by German armed forces. [PDF]

Eur Respir J
Pohl J, Gröschel MI, Neumann N, Tillmann A, Waldeck S, Schneider T, Overhoff D, Lange SG, Bucksch T, Peuker R, Rauschning D, Scheumann G, Scheit L, Schreiner M, Retro-TB-Bw-Study Group, Wenzel W, Kehe K, Friesen I, Dreyer V, Niemann S, Sander LE, Witzenrath M, Nouailles G, Zobel CM.   +23 more
europepmc   +1 more source