Results 131 to 140 of about 3,071,772 (281)

Tuberculosis in a South African prison - a transmission modelling analysis [PDF]

, 2011
Background. Prisons are recognised internationally as institutions with very high tuberculosis (TB) burdens where transmission is predominantly determined by contact between infectious and susceptible prisoners. A.
Bekker, LG, Johnstone-Robertson, S, Lawn, SD, Welte, A, Wood, R   +4 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Chronic obstructive pulmonary disease – importance of active case finding and consideration of comorbidities

Swiss Medical Weekly, 2017
Frank Rassouli
doaj   +1 more source

Perceptions of tuberculosis and home-based infection screening among families and providers in Madagascar: a qualitative study

BMC Public Health
Summary Background Madagascar is a country with a high tuberculosis (TB) burden, and the incidence of the disease has remained unchanged since 2013. TB detection largely relies on passive strategies, with little attention given to TB infections (TBIs ...
Voahirana Tantely Annick Andrianantoandro, Mamy Jean Jacques Razafimahatratra, Martine Audibert , Rila Ratovoson, Niaina Rakotosamimananan, Jonathan Hoffmann   +5 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Importance of confirmatory test characteristics in optimizing community-based screening for tuberculosis: an epidemiological modeling analysis

BMC Infectious Diseases
Background The costs, operational barriers, and sensitivity of available tools to confirm a TB diagnosis limit current active case-finding (ACF) efforts for tuberculosis (TB).
Lukas E. Brümmer, Theresa S. Ryckman, Sourya Shrestha, Florian M. Marx, William Worodria, Devasahayam J. Christopher, Grant Theron, Adithya Cattamanchi, Claudia M. Denkinger, David W. Dowdy, Emily A. Kendall   +10 more
doaj   +1 more source

Short and long term evaluations of Public Employment Services in Italy [PDF]

In the last decade the European Employment Strategy strongly recommended reforms of active labour market policies, reforms that have generated a spread of evaluation exercises for most of European countries.
Paolo Naticchioni, Silvia Loriga
core  

Tuberculosis active case-finding: more than just finding cases [PDF]

The Lancet Infectious Diseases, 2019
Carole D, Mitnick, Courtney M, Yuen
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source