Results 131 to 140 of about 14,005,924 (265)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Active Case Finding of Chronic Obstructive Pulmonary Disease in Romanian Primary Care. [PDF]

Medicina (Kaunas)
Iana AN, Gurgus D, Folescu R.
europepmc   +1 more source

Application of Management Science Techniques to Dental Practice Management

Operations Research ...
Emmons, Hamilton (Creatorcre), Reisman, Arnold (Creatorcre), Rivaud, Juan (Creatorcre), Green, Edward J. (Creatorcre), Morito, Susumu (Creatorcre)   +4 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Digital tools not enough; quality control-linked incentives are needed for tuberculosis active case finding. [PDF]

Public Health Action
Abdullah H, Shewade HD, Manickam P, Gupta K, Ambiya MS, Dhakad RS, Sharma K, Nag S, Shahnawaz M, Nagar R.   +9 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Prevalence of major risk factors for tuberculosis in COVID-19 active case-finding camps in India. [PDF]

Public Health Action
Arunachalam S, Chandra T, Basu A, Gandhi M, Shrivastava S, Shekhawat A, Singh M, Khanna A, Mannan S.   +8 more
europepmc   +1 more source

Analysis of the Reserve Book System at the Health Center Library

Operations Research ...
Mehta, Shailesh (Creatorcre), Darukhanavala, Phiroz P. (Creatorcre), Shroff, Pradip H. (Creatorcre), Dadachanji, Keki R. (Creatorcre)   +3 more
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Longitudinal Symptom Transitions Predict Incident Tuberculosis Risk in Serial Active Case Finding. [PDF]

J Infect Dis
Jung E, Bampi JVB, Moura da Silva A, Liu YE, Tsuha DH, Salindri AD, da Silva Santos A, de Oliveira RD, Croda J, Andrews JR.   +9 more
europepmc   +1 more source