Results 151 to 160 of about 790,871 (259)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Construction and Validation of Active Case-Finding Tool in Community Participants with Chronic Obstructive Pulmonary Disease Using an Interpretable Machine Learning Approach. [PDF]

Int J Chron Obstruct Pulmon Dis
Tian H, Wu F, Sun C, Deng Z, Zhou Y, Ran P.   +5 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Does active case finding detect TB early in programme settings? A national-level study in India. [PDF]

Public Health Action
Shewade HD, Kiran Pradeep S, Ravichandran P, Kiruthika G, Shah AN, Vadera B, Roddawar V, Mattoo SK, Iyer S, Tumu D, Chowdhury A, Devika S, Chadwick J, Vaidya RR, Singh P, Panda SK, Baig MA, Suma KV, Suleka M, Digal AK, Banerjee D, Prasanna ML, Waghela DY, Krishnaraj A, Kashyap P, Parmar JS, Mishra CK, Das S, Kumar A, Kumar A, Yadav S, Chetry S, Kumar A, Pathak M, Singh S, Tabrez S, Mehra P, Ramesh S, Bishnu B, Mahesh G, Rajesham A, Mishra BK, Chandra Tripathi U, Khayyam KU, Rade K, Rao R, Murhekar MV.   +46 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Active case finding for tuberculosis among Ukrainian soldiers by German armed forces. [PDF]

Eur Respir J
Pohl J, Gröschel MI, Neumann N, Tillmann A, Waldeck S, Schneider T, Overhoff D, Lange SG, Bucksch T, Peuker R, Rauschning D, Scheumann G, Scheit L, Schreiner M, Retro-TB-Bw-Study Group, Wenzel W, Kehe K, Friesen I, Dreyer V, Niemann S, Sander LE, Witzenrath M, Nouailles G, Zobel CM.   +23 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Short and long term evaluations of Public Employment Services in Italy [PDF]

In this paper we evaluate the efficacy of Public Employment Services in Italy (PESs) in increasing the unemployment to employment transition probabilities, through matching techniques.
Silvia LORIGA, Paolo, NATICHIONI
core  

Challenges and strategies of implementing active case finding for tuberculosis: A qualitative study at a high-burden primary healthcare center, Yogyakarta, Indonesia. [PDF]

Narra J
Nafiu HU, Padmawati RS, Bintoro BS.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source