Results 171 to 180 of about 790,871 (259)

Quality of active case-finding for tuberculosis in India: a national level secondary data analysis. [PDF]

Glob Health Action, 2023
Shewade HD, Kiruthika G, Ravichandran P, Iyer S, Chowdhury A, Kiran Pradeep S, Jeyashree K, Devika S, Chadwick J, Wesley Vivian J, Tumu D, Shah AN, Vadera B, Roddawar V, Mattoo SK, Rade K, Rao R, Murhekar MV.   +17 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Active case-finding for TB in India: Assessment of scale and quality benchmarks, time taken and use of rapid molecular diagnostic tests. [PDF]

PLOS Glob Public Health
Shewade HD, Pradeep SK, Ravichandran P, Kiruthika G, Shah AN, Vadera B, Sabarinathan R, Roddawar V, Mattoo SK, Iyer S, Tumu D, Chowdhury A, Devika S, Chadwick J, Vaidya RR, Hota PK, Frederick A, Singh P, Shanpru B, Khunger G, Panda SK, Baig MA, Suma KV, Suleka M, Digal AK, Banerjee D, Prasanna ML, Waghela DY, Krishnaraj A, Kashyap P, Parmar JS, Das S, Kumar A, Kumar A, Yadav S, Chetri S, Mahapatra SS, Kumar A, Pathak M, Singh S, Tabrez S, Mehra P, Bishnu B, Mahesh G, Mohanty B, Rajesham A, Mishra BK, Barot DN, Tripathi UC, Khayyam KU, Rade K, Rao R, Murhekar MV.   +52 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

National Active Case-Finding Program for Tuberculosis in Prisons, Peru, 2024. [PDF]

Emerg Infect Dis
Jung E, Alarcón VA, Solís Tupes WS, Avalos-Cruz T, Tovar M, Abregu E, Yang MZ, Andrews JR, Huaman MA.   +8 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Evaluation of an ultra-portable X-ray system with automated interpretation for tuberculosis active case finding in carceral settings: a diagnostic test accuracy study. [PDF]

BMC Infect Dis
Salindri AD, Bampi JVB, Busatto C, da Silva AM, da Silva Santos A, Gonçalves IB, Gonçalves TO, Cunha EAT, Tsuha D, Lemos E, de Oliveira RD, Croda M, Andrews JR, Croda J.   +13 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Impact of the use of the ultra-portable digital x-ray with CAD4TB for active case finding for tuberculosis in Nigeria. [PDF]

Front Digit Health
Alege A, Useni S, Ihesie A, Eneogu R, Agbaje A, Odume B, Nongo D, Chukwu E, Ogbudebe C, Oyelaran O, Anyomi C, Akingbesote S, Qin ZZ, Barrett R, Chijioke-Akaniro O, Anyaike C, Ewa A.   +16 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source