Results 71 to 80 of about 3,374,794 (302)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

COIL COUNTRY FOCUS

open access: yes, 2023
COIL virtual exchange (VE) links instructors and their students, usually based in higher education institutions in different countries, in collaborative practice and exchange. However, each country and region has its own somewhat localized approaches and
Hackett, Simone   +12 more
core   +1 more source

Lessons learned from hybrid surgery with preoperative coil embolization for an aberrant artery in pulmonary sequestration

open access: yesSurgical Case Reports, 2021
Background The optimal management of an aberrant artery in pulmonary sequestration (PS) is controversial. Several studies have shown that hybrid surgery with preoperative coil embolization for an aberrant artery and surgical resection of the sequestrated
Keita Nakanishi   +3 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

open access: yesFEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual   +3 more
wiley   +1 more source

Homodimerization through coiled‐coil regions enhances activity of the myotonic dystrophy protein kinase

open access: yesFEBS Letters, 2003
Myotonic dystrophy protein kinase (DMPK) is the protein product of the human DM‐1 locus on chromosome 19q13.1 and has been implicated in the cardiac and behavioral dysfunctions of the disorder. DMPK contains four distinct regions: a leucine‐rich repeat (L), a serine‐threonine protein kinase catalytic domain (PK), an α‐helical coiled‐coil region (H ...
Zhang, Rongxin, Epstein, Henry F.
openaire   +2 more sources

Flipper coil closure of patent ductus arteriosus [PDF]

open access: yes, 2007
Transcatheter closure of patent ductus arteriosus is now a well established therapeutic option. In this paper, we illustrate step by step the technique of Flipper coil closure of small (
DeGiovanni, Joseph V., Grech, Victor E.
core  

Co-expression of distinct L1 retrotransposon coiled coils can lead to their entanglement

open access: yesMobile DNA, 2023
L1 (LINE1) non-LTR retrotransposons are ubiquitous genomic parasites and the dominant transposable element in humans having generated about 40% of their genomic DNA during their ~ 100 million years (Myr) of activity in primates.
Nikola A. Mizgier   +2 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Assembly of helper NLR resistosome clusters upon activation of a coiled-coil NLR

open access: yesNature
Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors detect pathogen effectors and activate immunity1. Coiled-coil NLRs (CNLs) form resistosomes as Ca2+-permeable channels in the plasma membrane (PM)2-4. However, the mechanism by which resistosomes activate cell death remains unclear. Here we report that the CNL SUPPRESSOR OF mkk1 mkk2 2
Dongdong Ge   +9 more
openaire   +2 more sources

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