MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Segmentation of Left and Right Ventricles in Cardiac MRI Using Active Contours. [PDF]
Comput Math Methods Med, 2017 Soomro S +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Active Contours Connected Component Analysis Segmentation Method of Cancerous Lesions in Unsupervised Breast Histology Images. [PDF]
Bioengineering (Basel)Majanga V +3 more
europepmc +1 more source
Localized Patch-Based Fuzzy Active Contours for Image Segmentation. [PDF]
Comput Math Methods Med, 2016 Fang J, Liu H, Liu H, Zhang L, Liu J.
europepmc +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Light microscopy image segmentation using active contours driven by local image information for environmentally friendly fired-clay bricks design and characterization. [PDF]
PLoS OneBaloi AM, Streza M, Belean B.
europepmc +1 more source
Accurate Morphology Preserving Segmentation of Overlapping Cells based on Active Contours. [PDF]
Sci Rep, 2016 Molnar C +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Incorporating Radar Frequency-Domain Deramping into Variational Shape-Based Scene Reconstruction: A Feasibility Study Using Active Contours. [PDF]
Sensors (Basel)Yildirim A +3 more
europepmc +1 more source