Results 61 to 70 of about 893,458 (334)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Biomarker Response to Galactic Cosmic Ray-Induced NOx and the Methane Greenhouse Effect in the Atmosphere of an Earthlike Planet Orbiting an M-Dwarf Star [PDF]

, 2007
Planets orbiting in the habitable zone (HZ) of M-Dwarf stars are subject to high levels of galactic cosmic rays (GCRs) which produce nitrogen oxides in earthlike atmospheres.
Grenfell, John Lee, Griessmeier, Jean-Mathias, Patzer, Beate, Rauer, Heike, Segura, Antigona, Stadelmann, Anja, Stracke, Barbara, Titz, Ruth, von Paris, Philip   +8 more
core   +4 more sources

Engineering kinematic theory of the contact earth pressure and its application to the static calculation of thin quay walls [PDF]

Инженерно-строительный журнал, 2013
Construction of deep-water thrust berthing structures requires using new and more perfect methods of calculation containing fewer assumptions. A version of the engineering kinematic theory of contact earth pressure in the application to the water ...
V.S. Korovkin
doaj   +1 more source

Probabilistic analysis of the active earth pressure on earth retaining walls for c-ϕ soils according to the Mazindrani and Ganjali method

International Journal of Geo-Engineering, 2021
The determination of the earth pressure coefficients (K) in geotechnical engineering is one of the most critical procedures in designing earth retaining walls.
J. Osorio, J. Viviescas, J. Osorio
semanticscholar   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Active earth pressure calculation method for gravity retaining wall of railway subgrade based on discretized potential sliding surface inclination angle

Yantu gongcheng xuebao
The cross-section of the backfill behind railway subgrade gravity retaining walls is trapezoidal, and the backfill is subjected to train loads. General formulas of Coulomb earth pressure theory are not applicable for the determination of the location of ...
LI Bin1, , YUAN Jinquan2, ZHANG Lianyu3 , CAO Zijun4, 5, YAO Hongxi6, CHEN Rong3, 5
doaj   +1 more source

Method for efficient calculating earth pressure of retaining wall considering plant transpiration

Scientific Reports, 2023
An accurate estimation of earth pressure on retaining walls is imperative to achieving its design. This paper presents an analytical method framework that considers the effect of plant transpiration relative to the traditional calculation approaches ...
Junhui Zhang, Huiren Hu, Wei Fu, Junhui Peng, Feng Li, Le Ding   +5 more
doaj   +1 more source

The Atmospheric Chemistry of GJ 1214b: Photochemistry and Clouds [PDF]

, 2011
Recent observations of the transiting super-Earth GJ 1214b reveal that its atmosphere may be hydrogen-rich or water-rich in nature, with clouds or hazes potentially affecting its transmission spectrum in the optical and very-near-IR.
Asplund, Batalha, Berta, Borucki, Cooper, Croll, Dobbs-Dixon, Désert, Eliza Miller-Ricci Kempton, Fortney, Fortney, Fortney, Freedman, Hauschildt, Hubbard, Jonathan J. Fortney, Kevin Zahnle, Kundurthy, Liang, Line, Lodders, Madhusudhan, Madhusudhan, Miller-Ricci, Miller-Ricci, Moses, Nettelmann, Rauscher, Rogers, Seager, Seager, Shabram, Showman, Swain, Swain, Visscher, Zahnle, Zahnle   +37 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source