Results 141 to 150 of about 603,998 (309)

Segmentation of Fault Networks Determined from Spatial Clustering of Earthquakes

, 2010
We present a new method of data clustering applied to earthquake catalogs, with the goal of reconstructing the seismically active part of fault networks.
Allégre, Ben-Zion, Ben-Zion, Bishop, Bowman, Corduneanu, D. Sornette, de Joussineau, Duda, Eneva, Faulkner, G. Ouillon, Gardner, Hauksson, Hauksson, Helmstetter, Helmstetter, Helmstetter, Helmstetter, Kagan, Kagan, Kagan, Kagan, Kagan, Kagan, Kilb, Knopoff, Liu, Lyakhovsky, MacQueen, Manighetti, Marsan, Martel, Martel, Miltenberger, Nemser, Ouillon, Ouillon, Ouillon, Ouillon, Pisarenko, Plesch, Powers, Reasenberg, Robertson, Scholz, Scholz, Sornette, Sornette, Sornette, Sornette, Sornette, Sornette, Sornette, Sornette, Vermilye, Waldhauser, Wang, Weatherley, Willemse, Wilson, Zhou, Zhuang, Zhuang   +63 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Influence of Digital Elevation Model Resolution on the Normalized Stream Length–Gradient Index in Intraplate Regions: A Case Study of the Yangsan Fault, Korea

Remote Sensing
The spatial variability of input parameters plays a crucial role in the interpretation of geomorphic indices, with digital elevation models (DEMs) being the primary data source.
Hyunjee Lim, Sangmin Ha, Sohee Kim, Hee-Cheol Kang, Moon Son   +4 more
doaj   +1 more source

Effect of active faults in the groundwater level of Shaharchay basin in Urmia [PDF]

تحقیقات کاربردی علوم جغرافیایی, 2017
حذف شدیک جمله Identify water resources management and proper application of relevant officials and managers are the main concern. Groundwater as a most important natural resources of Iran needs to planning and management of all aspects. In this regard, a
Tayebeh Kiani, Zahra Yousefi
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Possible role of crustal flexure in the initial detachment of extensional allochthons [PDF]

The existence of low-angle normal faults indicates that the ratio of shear stress (TAU) to normal stress (sigma sub N) needed to cause slip on faults is substantially less than would be predicted based on experimental data. Because the tensional strength
Spencer, J. E.
core   +1 more source

An Advanced Three-Level Active Neutral-Point-Clamped Converter With Improved Fault-Tolerant Capabilities [PDF]

, 2017
A resilient fault-tolerant silicon carbide (SiC) three-level power converter topology is introduced based on the traditional active neutral-point-clamped converter.
He, Jiangbiao, Katebi, Ramin, Weise, Nathan   +2 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The strong earthquakes and seismogenic structures in eastern margin of Tibetan Plateau and adjacent areas: A preface for the special topic

地震科学进展
The eastern margin of the Tibetan Plateau is composed of multiple secondary tectonic units which constitute typical “multi-level extrusion-rotation active tectonic system”.
Zhonghai Wu, Zhongtai He, Ning Zhong, Jingxing Yu, Bo Zhang   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source