GeosciencesEstablishing the absolute age of palaeoearthquakes is of great significance for the assessment of the seismicity and seismic hazards of a region. As such, several different geochronological techniques to date earthquake-related material have been ...
Evangelos Tsakalos +5 more
doaj +1 more source
Kinematics at the intersection of the Garlock and Death Valley fault zones, California: Integration of TM data and field studies [PDF]
The Garlock and Death Valley fault zones in SE California are two active strike-slip faults coming together on the east side of the Avawatz Mtns.
Abrams, Michael +3 more
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Definitions, Classification Schemes for Active Faults, and Their Application
GeosciencesActive faults are generally defined as faults that have moved in the past and will continue to be active in the future. They are expected to cause deformation and potential disasters if they are localized close to human activities.
Zhonghai Wu, Mengmeng Hu
doaj +1 more source
FEBS Open Bio, EarlyView.We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima +4 more
wiley +1 more source
Block Structure Bounded by Active Strike-slip Faults in the Northern Part of Kinki District, Southwest Japan [PDF]
, 1990 Geological and geophysical surveys were carried out to discover the hidden active faults and to estimate the dimensions of fractured zone in the northern part of Kinki district, southwest Japan.
Katsura, Ikuo
core
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
FEBS Open Bio, EarlyView.Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source
TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, EarlyView.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source
Using integrated geophysics data set to delineate Phetchabun active fault in Thailand. [PDF]
Data Brief, 2020 Arjwech R +4 more
europepmc +1 more source