Results 81 to 90 of about 4,733,293 (337)

Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases

FEBS Letters, EarlyView.
Igor Zivkovic, Morana Dulic, Ita Gruic‐Sovulj   +2 more
wiley   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Stratigraphic and structural evidence of transpressional Quaternary fault reactivation along the SE Korean Peninsula

Quaternary Science Advances
Comprehending the nature, extent, and distribution of seismogenic structures, along with their seismogenic potential to induce destructive earthquakes in low seismic strain regions, holds significant socio-economic significance.
Sambit Prasanajit Naik, Kiwoong Park, Francois Hategekimana, Hyeon Cho Shin, Young-Seog Kim   +4 more
doaj  

Active fault-tolerant control approach design for rigid spacecraft with multiple actuator faults

J. Syst. Control. Eng., 2018
In this study, the active fault-tolerant control problem is investigated for a rigid spacecraft in the presence of inertia uncertainty, external disturbance, multiple actuator faults and actuator saturation.
Zhifeng Gao, P. Cheng, Moshu Qian, Guoping Jiang, Jinxing Lin   +4 more
semanticscholar   +1 more source

Active faulting near Taupo

Eos, Transactions American Geophysical Union, 1984
The only confirmed fault displacement in New Zealand since that accompanying the 1968 Inangahua Earthquake was observed on June 23 and 24, 1983, 4 km west of Taupo in the Taupo Volcanic Zone, central North Island (Figure 1). Normal displacement occurred on the late Quaternary Kaiapo fault, previously active in 1922, when almost 1 m of normal fault ...
George W. Grindley, Alan G. Hull
openaire   +2 more sources

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Using the Active Faults of Eurasia Database for solving tectonic problems

Геодинамика и тектонофизика, 2019
The article describes principles, methods and tasks of tectonic studies using computer processing of the Active Faults of Eurasia Database. This new database contains more than 30000 objects that are geographically linked, equipped with attributes of the
D. M. Bachmanov, E. A. Zelenin, A. I. Kozhurin, V. G. Trifonov   +3 more
doaj   +1 more source

Active Fault Isolation for Multimode Fault Systems Based on a Set Separation Indicator. [PDF]

Entropy (Basel), 2023
Han K, Lu S, Liu Z, Wang Z.
europepmc   +1 more source

Active fault tolerant control based on a neuro fuzzy inference system applied to a two shafts gas turbine

Applied Artificial Intelligence, 2018
The main aim of the present work is development of an active fault tolerant control for two shafts gas turbine fault detection and isolation based on a neuro fuzzy inference system adaptive approach.
Nadji Hadroug, A. Hafaifa, N. Batel, A. Kouzou, A. Chaibet   +4 more
semanticscholar   +1 more source