Results 71 to 80 of about 118,708 (290)

Tau and β-Amyloid Relevant Pathology as a Central Therapeutic Target in Alzheimer’s Disease

Biomolecules
Alzheimer’s disease (AD) is the leading cause of dementia, responsible for approximately 60–70% of cases globally. AD is a gradually progressive neurodegenerative disorder that is characterized by widespread deposition of β-amyloid (Aβ) plaques, followed
Lidia Strużyńska, Kamil Adamiak, Marta Sidoryk-Węgrzynowicz   +2 more
doaj   +1 more source

Bilateral SERS‐Microneedle Patch for Co‐Diagnosis of Diabetes Mellitus and Tuberculosis Comorbidity

Advanced Science, EarlyView.
Our study introduced a U@mP@Au‐mediated bilateral SERS‐microneedle patch for analyzing glucose levels from ISF and sensitively detecting TB biomarkers from sputum, respectively. This integrated dual‐analyte detecting platform can be used for co‐diagnosis of diabetes mellitus (DM) and tuberculosis (TB) comorbidity, which was demonstrated in ex vivo ...
Xueqin Huang, Lingzhi Chen, Jing Xu, Jiaqi Yu, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Lang Rao, Jierong Chen, Junxia Zheng, Haibo Zhou   +12 more
wiley   +1 more source

IIS Functional Standards v4.0 [PDF]

The Immunization Information System (IIS) Functional Standards describe the operations, dataquality, and technology needed by IISs to support immunization programs, vaccinationproviders, and other immunization stakeholders.

core  

Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleonopathies

, 2017
Objectives: Parkinson’s Disease (PD), Dementia with Lewy bodies (DLB), and Multiple System Atrophy (MSA) are neurodegenerative disorders of the aging population characterized by the progressive accumulation of alpha-synuclein.
Adame, Anthony, Masliah, Eliezer, Rockenstein, Edward, Dikengil, Fusun, Rus, Florentina, Florio, Jazmin, Ostroff, Gary R, Overk, Cassia, Mante, Michael, Trinh, Ivy, Rissman, Robert   +10 more
core   +2 more sources

Guiding the security protection of critical information infrastructure with scientific network security concept

物联网学报, 2019
In the current increasingly competitive international cyberspace security game,critical information infrastructure is facing a severe security situation.From the view of scientific principle,the essence of network security risk is the limitation of ...
Yangzhao LI, Changxiang SHEN, Nan TIAN
doaj  

The natural human adaptive IgG-specific immune response is skewed towards non-protective tail domains of DNABII proteins

Frontiers in Immunology
Biofilm-mediated infections are highly recalcitrant to antibiotics and host immune system clearance. The matrix that envelopes biofilm-resident bacteria is stabilized by extracellular DNA as well as integrated ubiquitous bacterial DNABII proteins that ...
Kathryn Q. Wilbanks, Jaime D. Rhodes, Steven D. Goodman, Steven D. Goodman, Sanjay Sethi, Sanjay Sethi, Timothy F. Murphy, Lauren O. Bakaletz, Lauren O. Bakaletz   +8 more
doaj   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Targeting Clostridium difficile Surface Components to Develop Immunotherapeutic Strategies Against Clostridium difficile Infection

Frontiers in Microbiology, 2018
New therapies are needed to prevent and treat Clostridium difficile infection and to limit the rise in antibiotic resistance. Besides toxins, several surface components have been characterized as colonization factors and have been shown as immunogenic ...
Séverine Péchiné, Jean F. Bruxelle, Claire Janoir, Anne Collignon   +3 more
doaj   +1 more source

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source

Attacking the public health crisis of hepatocellular carcinoma at its roots

Hepatology, EarlyView., 2022
Abstract As the third most common cause of cancer‐related death worldwide with significant mortality rates in the United States, hepatocellular carcinoma has strong association with cirrhosis and chronic hepatitis B virus (HBV) with a growing at‐risk population from the rise in chronic liver disease from alcohol use and nonalcoholic fatty liver disease.
Hannah M. Lee, Steven D. Lidofsky, Tamar H. Taddei, Lisa J. Townshend‐Bulson   +3 more
wiley   +1 more source