Results 121 to 130 of about 82,572 (267)
Cross-Layer Peer-to-Peer Track Identification and Optimization Based on Active Networking [PDF]
, 2005 P2P applications appear to emerge as ultimate killer applications due to their ability to construct highly dynamic overlay topologies with rapidly-varying and unpredictable traffic dynamics, which can constitute a serious challenge even for significantly
Pezaros, D. +6 more
core
Fluxes and (co-)variances of reacting scalars in the convective boundary layer
, 2002 The effects of chemistry on the transport and the mixing of reacting scalars in the convective atmospheric boundary layer (CBL) are investigated. To do this, we use large-eddy simulation (LES) to calculate explicitly the different terms of the flux and ...
Vinuesa, J. +2 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Active Control of Ionized Boundary Layers [PDF]
International Journal of Bifurcation and Chaos, 1998 The challenging problems, in the field of control of chaos or of transition to chaos, lie in the domain of infinite-dimensional systems. Access to all variables being impossible in this case and the controlling action being limited to a few collective variables, it will not in general be possible to drive the whole system to the desired behavior.
openaire +2 more sources
Polarimetric Investigation of a Two Surface Layer Structure
, 2010 One of the challenges of future planetary SAR missions will be the estimation of surface and subsurface geometric and dielectric characteristics.
Papathanassiou, Konstantinos P. +1 more
core
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Single active layer electrochromic devices
, 2023 In one embodiment, an electrochromic device includes a single active layer configured to be alternately placed in a light-transmitting state in which relatively large amounts of light can be transmitted through the active layer and a light-blocking state
Ram, Manoj Kumar, Stefanakos, Elias K.
core