Results 61 to 70 of about 5,429,053 (296)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Feeding Activity of Caged Layers

open access: yesPoultry Science, 1971
Abstract In planning an experiment involving blood sampling at known times after ingestion of food, it was evident that the pattern of feeding of laying hens during the day required investigation first. Several investigators have examined the effects of environmental temperature on total daily or weekly feed intake (Huston et al., 1957; Squibb, 1959;
openaire   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Thaw-Season InSAR Surface Displacements and Frost Susceptibility Mapping to Support Community-Scale Planning in Ilulissat, West Greenland

open access: yesRemote Sensing, 2023
In permafrost regions, ground surface deformations induced by freezing and thawing threaten the integrity of the built environment. Mapping the frost susceptibility of the ground at a high spatial resolution is of practical importance for the ...
Johanna Scheer   +6 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

An Assessment of the Possibility of Restoration and Protection of Territories Disturbed by Thermokarst in Central Yakutia, Eastern Siberia

open access: yesLand, 2023
Rapid permafrost degradation is observed in northern regions as a result of climate change and expanding economic development. Associated increases in active layer depth lead to thermokarst development, resulting in irregular surface topography.
Aleksandr Zhirkov   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

The case for active block layer extensions [PDF]

open access: yesACM SIGOPS Operating Systems Review, 2008
Self-managing storage systems have recently received attention from the research community due to their promised ability of continuously adapting to best reflect high-level system goal specifications. However, this eventuality is currently being met by both conceptual and practical challenges that threaten to slow down the pace of innovation.
Jorge Guerra   +4 more
openaire   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Active boundary layers

open access: yes, 2020
The role of boundary layers in conventional liquid crystals is commonly subsumed in their anchoring on confining walls. In the classical view, anchoring enslaves the orientational field of the passive material under equilibrium conditions. In this work, we experimentally explore the role of confining walls in the behavior of an active nematic.
Hardoüin, Jérôme   +5 more
openaire   +2 more sources

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