Results 71 to 80 of about 5,429,053 (296)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

An insolation activated dust layer on Mars [PDF]

Icarus, 2015
The illuminated dusty surface of Mars acts like a gas pump. It is driven by thermal creep at low pressure within the soil. In the top soil layer this gas flow has to be sustained by a pressure gradient. This is equivalent to a lifting force on the dust grains. The top layer is therefore under tension which reduces the threshold wind speed for saltation.
de Beule, Caroline, Wurm, Gerhard, Kelling, Thorben, Köster, Marc, Kocifaj, Miroslav   +4 more
openaire   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Predicting Seasonal Deformation Using InSAR and Machine Learning in the Permafrost Regions of the Yangtze River Source Region

Water Resources Research
Quantifying seasonal deformation is essential for accurately determining the thickness of the active layer and the distribution of water content within it, providing insights into the freeze‐thaw dynamics of permafrost environments and their sensitivity ...
Jie Chen, Xingchen Lin, Tonghua Wu, Junming Hao, Xiaodong Wu, Defu Zou, Xiaofan Zhu, Guojie Hu, Yongping Qiao, Dong Wang, Sizhong Yang, Lina Zhang   +11 more
doaj   +1 more source

Air Convection in the Active Layer of Rock Glaciers

Frontiers in Earth Science, 2020
Coarse blocks are an abundant surface cover in mountainous permafrost landscapes. In this coarse blocky layer, air convection occurs and has a significant influence on the ground thermal regime of the underlying permafrost.
Jonas Wicky, Christian Hauck
doaj   +1 more source

Kinetics of Ion Transport in Perovskite Active Layers and Its Implications for Active Layer Stability

Journal of the American Chemical Society, 2015
Solar cells fabricated using alkyl ammonium metal halides as light absorbers have the right combination of high power conversion efficiency and ease of fabrication to realize inexpensive but efficient thin film solar cells. However, they degrade under prolonged exposure to sunlight. Herein, we show that this degradation is quasi-reversible, and that it
Monojit, Bag, Lawrence A, Renna, Ramesh Y, Adhikari, Supravat, Karak, Feng, Liu, Paul M, Lahti, Thomas P, Russell, Mark T, Tuominen, D, Venkataraman   +8 more
openaire   +3 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Identification of Thermally-Tagged Coherent Structures in the Zero Pressure Gradient Turbulent Boundary Layer [PDF]

, 2013
A zero pressure gradient boundary layer over a flat plate is subjected to step changes in thermal condition at the wall, causing the formation of internal, heated layers.
Rought, Rebecca Lynn
core   +1 more source