Results 31 to 40 of about 576,878 (282)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Batch Mode Active Learning Based on Multi-Set Clustering

IEEE Access, 2021
Batch mode active learning, where a batch of samples is simultaneously selected and labeled, is a challenging task. The challenge lies in how to maintain the informativeness and keep the diversity of selected samples concurrently.
Yazhou Yang, Xiaoqing Yin, Yang Zhao, Jun Lei, Weili Li, Zhe Shu   +5 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

How to Help Young Children Ask Better Questions?

Frontiers in Psychology, 2021
In this paper, we investigate the informativeness of 4- to 6-year-old (N = 125) children’s questions using a combined qualitative and quantitative approach.
Azzurra Ruggeri, Azzurra Ruggeri, Caren M. Walker, Tania Lombrozo, Alison Gopnik   +4 more
doaj   +1 more source

Semantic Segmentation with Active Semi-Supervised Representation Learning [PDF]

, 2022
Aneesh Rangnekar, Christopher Kanan, Matthew Hoffman   +2 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Efficacy of trimebutine maleate as treatment for patients with functional gastrointestinal disorders: a multicenter prospective trial [PDF]

Pharmacia
Trimebutine, a selective antispasmodic and gastrointestinal motility modulator, was evaluated for symptom control in functional dyspepsia and overlapping functional gastrointestinal disorders.
Kamen Valentinov Danov, Dariya Lyubomirova Todorova, Mina Stamenova Kotchkova, Maria Sevdelinova Chaneva, Angelina Georgieva Kirkova-Bogdanova, Maria Stamova Vakrilova Becheva, Maria Georgieva Moneva-Sakelarieva, Yozlem Ali Kobakova, Ventseslava Petrova Atanasova, Radoslav Fedeev Todorov, Nikolay Zarkov Bashev, Ismail Elhanov Bashov, Yonko Tsvetanov Yonchev, Vasil Sotirov Kyosev, Konstantin Ivanov Kostov, Kiril Todorov Atliev, Niya Emilova Semerdzhieva, Adel Habib Ibrahim, Petar Yordanov Atanasov, Stefka Achkova Ivanova   +19 more
doaj   +3 more sources

Applying the Plan-Do-Study-Act cycle in medical education to refine an antibiotics therapy active learning session [PDF]

, 2021
Stacey Rose, Richard J. Hamill, Andrew Caruso, Nital Appelbaum   +3 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Current teachers’ perceptions and students' perspectives regarding activities modalities, instructional settings during primary school physical education classes in China: a cross-sectional observational study

Frontiers in Sports and Active Living
IntroductionThis study set out to understand the association between teaching practices, teacher confidence, competence, self-efficacy, and the resulting student outcomes.MethodsData regarding teaching behaviours were collected via video recording and ...
Jin Yan, Jin Yan, Jin Yan, Max Malkin, Max Malkin, Jordan J. Smith, Jordan J. Smith, Philip Morgan, Philip Morgan, Narelle Eather, Narelle Eather   +10 more
doaj   +1 more source