Results 41 to 50 of about 611,278 (267)

The Effects of Violence and Aggression From Parents on Child Protection Workers’ Personal, Family, and Professional Lives

SAGE Open, 2016
This article presents findings from a survey of the experiences of child protection workers in England when working with parents who exhibit aggression and violence. This work explores the effects on workers in their professional lives, and on themselves
Brian Littlechild, Susan Hunt, Chris Goddard, Judy Cooper, Barry Raynes, James Wild   +5 more
doaj   +1 more source

Behaviours that prompt primary school teachers to adopt and implement physically active learning: a meta synthesis of qualitative evidence

International Journal of Behavioral Nutrition and Physical Activity, 2021
Background Physically active learning (PAL) - integration of movement within delivery of academic content - is a core component of many whole-of-school physical activity approaches. Yet, PAL intervention methods and strategies vary and frequently are not
Andrew Daly-Smith, Jade L. Morris, Emma Norris, Toni L. Williams, Victoria Archbold, Jouni Kallio, Tuija H. Tammelin, Amika Singh, Jorge Mota, Jesper von Seelen, Caterina Pesce, Jo Salmon, Heather McKay, John Bartholomew, Geir Kare Resaland   +14 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Antibiotic treatment in sepsis–etiological structure, antibiotic resistance, and pharmacological challenges: A retrospective analysis [PDF]

Pharmacia
This retrospective study evaluates the etiological spectrum, antimicrobial resistance patterns, and pharmacokinetic/pharmacodynamic (PK/PD) challenges in patients with sepsis treated at the Clinic of Internal Diseases, UMBALSM “N. I. Pirogov,” Sofia.
Yozlem Ali Kobakova, Angelina Georgieva Kirkova-Bogdanova, Maria Stamova Vakrilova Becheva, Niya Emilova Semerdzhieva, Stefka Achkova Ivanova, Maria Sevdelinova Chaneva, Ventseslava Petrova Atanasova, Ismail Elhanov Bashov, Yonko Tsvetanov Yonchev, Radoslav Fedeev Todorov, Nikolay Zarkov Bashev, Diana Nikolaeva Teneva, Kamen Valentinov Danov, Maria Georgieva Moneva-Sakelarieva, Kiril Todorov Atliev, Vasil Sotirov Kyosev, Silviya Milchova Pavlova, Petar Yordanov Atanasov   +17 more
doaj   +3 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Current teachers’ perceptions and students' perspectives regarding activities modalities, instructional settings during primary school physical education classes in China: a cross-sectional observational study

Frontiers in Sports and Active Living
IntroductionThis study set out to understand the association between teaching practices, teacher confidence, competence, self-efficacy, and the resulting student outcomes.MethodsData regarding teaching behaviours were collected via video recording and ...
Jin Yan, Jin Yan, Jin Yan, Max Malkin, Max Malkin, Jordan J. Smith, Jordan J. Smith, Philip Morgan, Philip Morgan, Narelle Eather, Narelle Eather   +10 more
doaj   +1 more source

Exploring the self-reported physical fitness and self-rated health, mental health disorders, and body satisfaction among Chinese adolescents: A cross-sectional study

Frontiers in Psychology, 2022
BackgroundPhysical activity (PA) and Physical fitness (PF) have received tremendous attention in the field of physical and mental health. However, limited attention has been given to the associations of self-reported physical fitness with some health ...
Chongyan Shi, Jin Yan, Jin Yan, Lei Wang, Hejun Shen   +4 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Efficacy of trimebutine maleate as treatment for patients with functional gastrointestinal disorders: a multicenter prospective trial [PDF]

Pharmacia
Trimebutine, a selective antispasmodic and gastrointestinal motility modulator, was evaluated for symptom control in functional dyspepsia and overlapping functional gastrointestinal disorders.
Kamen Valentinov Danov, Dariya Lyubomirova Todorova, Mina Stamenova Kotchkova, Maria Sevdelinova Chaneva, Angelina Georgieva Kirkova-Bogdanova, Maria Stamova Vakrilova Becheva, Maria Georgieva Moneva-Sakelarieva, Yozlem Ali Kobakova, Ventseslava Petrova Atanasova, Radoslav Fedeev Todorov, Nikolay Zarkov Bashev, Ismail Elhanov Bashov, Yonko Tsvetanov Yonchev, Vasil Sotirov Kyosev, Konstantin Ivanov Kostov, Kiril Todorov Atliev, Niya Emilova Semerdzhieva, Adel Habib Ibrahim, Petar Yordanov Atanasov, Stefka Achkova Ivanova   +19 more
doaj   +3 more sources