Results 71 to 80 of about 10,830,582 (300)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Efficacy of trimebutine maleate as treatment for patients with functional gastrointestinal disorders: a multicenter prospective trial [PDF]

Pharmacia
Trimebutine, a selective antispasmodic and gastrointestinal motility modulator, was evaluated for symptom control in functional dyspepsia and overlapping functional gastrointestinal disorders.
Kamen Valentinov Danov, Dariya Lyubomirova Todorova, Mina Stamenova Kotchkova, Maria Sevdelinova Chaneva, Angelina Georgieva Kirkova-Bogdanova, Maria Stamova Vakrilova Becheva, Maria Georgieva Moneva-Sakelarieva, Yozlem Ali Kobakova, Ventseslava Petrova Atanasova, Radoslav Fedeev Todorov, Nikolay Zarkov Bashev, Ismail Elhanov Bashov, Yonko Tsvetanov Yonchev, Vasil Sotirov Kyosev, Konstantin Ivanov Kostov, Kiril Todorov Atliev, Niya Emilova Semerdzhieva, Adel Habib Ibrahim, Petar Yordanov Atanasov, Stefka Achkova Ivanova   +19 more
doaj   +3 more sources

Exploring the self-reported physical fitness and self-rated health, mental health disorders, and body satisfaction among Chinese adolescents: A cross-sectional study

Frontiers in Psychology, 2022
BackgroundPhysical activity (PA) and Physical fitness (PF) have received tremendous attention in the field of physical and mental health. However, limited attention has been given to the associations of self-reported physical fitness with some health ...
Chongyan Shi, Jin Yan, Jin Yan, Lei Wang, Hejun Shen   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Current teachers’ perceptions and students' perspectives regarding activities modalities, instructional settings during primary school physical education classes in China: a cross-sectional observational study

Frontiers in Sports and Active Living
IntroductionThis study set out to understand the association between teaching practices, teacher confidence, competence, self-efficacy, and the resulting student outcomes.MethodsData regarding teaching behaviours were collected via video recording and ...
Jin Yan, Jin Yan, Jin Yan, Max Malkin, Max Malkin, Jordan J. Smith, Jordan J. Smith, Philip Morgan, Philip Morgan, Narelle Eather, Narelle Eather   +10 more
doaj   +1 more source

Cross-cultural adaptation and validation of a Resistance Training Skill Battery for use in Chinese-speaking adolescents [PDF]

PeerJ
Purpose Although the Resistance Training Skills Battery (RTSB) is a well-established instrument for assessing resistance training (RT) skill competency in Western populations, its applicability to Chinese adolescents remains unvalidated. This study aimed
Xiaolu Zha, David Lubans, Jordan Smith, Ran Wang   +3 more
doaj   +2 more sources

On the Robustness of Active Learning

EPiC Series in Computing, 2019
Active Learning is concerned with the question of how to identify the most useful samples for a Machine Learning algorithm to be trained with. When applied correctly, it can be a very powerful tool to counteract the immense data requirements of Artificial Neural Networks.
Lukas Hahn, Lutz Roese-Koerner, Peet Cremer, Urs Zimmermann, Ori Maoz, Anton Kummert   +5 more
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source