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Asymmetric Synthesis of Active Pharmaceutical Ingredients
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Vittorio, Farina +3 more
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Active Pharmaceutical Ingredients
2005Introduction. Process Development. Technology Transfer. Plant Design & Construction. Regulatory Requirements. Process Validation. Quality Assurance and Control. Plant Operations. Materials Management.
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Precision Active Pharmaceutical Ingredients are the Goal
Future Medicinal Chemistry, 2016Understanding and exploiting molecular mechanisms in biology is central to chemical biology. Chemical biology studies of biological macromolecules are now in a perfect continuum with molecular level and nanomolecular level mechanistic studies involving whole organisms.
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Polymorphism of Active Pharmaceutical Ingredients
Chemical Engineering & Technology, 2006AbstractDifferent polymorphs of the same active pharmaceutical ingredient (API) display distinct physical properties, such as melting point, solubility, dissolution rate, hygroscopicity, or stability. The ability to successfully produce and reproduce specific stable polymorphs is intricately correlated with the efficiency and speed of drug development,
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Investigation of active pharmaceutical ingredient loss in pharmaceutical compounding of capsules
Journal of Pharmaceutical and Biomedical Analysis, 2014Pharmaceutical compounding of capsules is still an important corner stone in today's health care. It allows for a more patient specific treatment plan as opposed to the "one size fits all"-approach, used by the pharmaceutical industry when producing fixed dose finished drug products. However, loss of active pharmaceutical ingredient (API) powder during
Matthias, D'Hondt +8 more
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Stable isotopic characterization of active pharmaceutical ingredients
Journal of Pharmaceutical and Biomedical Analysis, 2004Stable isotopic characterization or "fingerprinting" of active pharmaceutical ingredients (APIs) is a highly-specific means of defining the provenance of these pharmaceutical materials. The isotopic analysts in this study were provided with 20 blind samples of four APIs (tropicamide, hydrocortisone, quinine HCL, and tryptophan) from one-to-five ...
J P, Jasper +4 more
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active (pharmaceutical) ingredient (API)
2009Pharmacologically active part(s) of a formulation; in case of a salt, the active ingredient should be understood to include both, the therapeutic moiety and the appended portion of the molecule; the maximum acceptable deviation in the a.i. content of a finished product must not exceed ±5% at the time of manufacture → see also drug, medicinal product.
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Excipients and Active Pharmaceutical Ingredients
2014Raw materials in pediatric formulations such as excipients, food ingredients, and active pharmaceutical ingredients (APIs) have received significant attention from regulatory agencies worldwide in recent times due to safety concerns. Not all excipients and food ingredients are “inert” and have been shown to interfere with the growth and development ...
Parnali Chatterjee, Mohammed M. Alvi
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Milling of Active Pharmaceutical Ingredients
2013Physical properties of active pharmaceutical ingredients (APIs) can impact their effectiveness in the body and influence formulation development and design. In most cases, it is necessary to reduce particle size, which is frequently accomplished by comminution or milling.
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