Results 71 to 80 of about 3,741,697 (242)

A Rapid Method for Screening Crystallization Conditions and Phases of an Active Pharmaceutical Ingredient

, 2009
Here we present a useful methodology for rapid screening of crystallization conditions and phases in the pharmaceutical industry using a multiwell setup with video-microscopy developed in our laboratory.
Klein, J.P., Veesler, S., Teston, J.L., Detoisien, T., Colson, D., Forite, M., Taulelle, P.   +6 more
core   +1 more source

Improving stereoselectivity of phosphotriesterase (PTE) for kinetic resolution of chiral phosphates

Frontiers in Bioengineering and Biotechnology
Specific stereoisomer is paramount as it is vital for optimizing drug efficacy and safety. The quest for the isolation of desired stereoisomer of active pharmaceutical ingredients or key intermediates drives innovation in drug synthetic and biocatalytic ...
Nongluck Jaito, Suthathip Phetlum, Titiporn Saeoung, Thanat Tiyasakulchai, Nitipol Srimongkolpithak, Tanaporn Uengwetwanit   +5 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Interactions between Active Ingredient Ranitidine and Clay Mineral Excipients in Pharmaceutical Formulations

, 2020
Excipients play an important role in pharmaceutical formulations. Many clay minerals, because of their large specific surface area and inert behaviour in reactions with active ingredients, are commonly used as excipients.
Zhaohui Li, Libing Liao, Xisen Wang, Hui Yin, Qingfeng Wu, Lijuan Wang   +5 more
core   +1 more source

Bacterial nano cellulose as non-active pharmaceutical ingredient: Advances and perspectives [PDF]

, 2018
Nano Cellulose is commonly produced by the top-down enzymatic, mechanical and/or chemical treatments. In contrast, Bacterial Nano Cellulose (BNC) can be obtained by a bottom-up approach, where is biosynthesized from glucose using the direct action of ...
Sesto Cabral, María Eugenia, Moreno, María Julieta, González, Exequiel Elías, Cerúsico, Nicolás Abel   +3 more
core   +1 more source

Editorial: Separation Processes in Pharmaceutical Manufacturing

Frontiers in Chemical Engineering, 2022
Cristina Chuck-Hernández, Jia Wei Chew, Karla Mayolo-Deloisa, Bodhisattwa Chaudhuri, Bodhisattwa Chaudhuri   +4 more
doaj   +1 more source

Pramipexole Symmetric and Asymmetric Potentiometric PVC Membrane Sensors

International Journal of Electrochemical Science, 2016
Pramipexole is one of the prescribed medication for Parkinson's disease, which is a dopamine agonist of the non-ergoline class. Due to the importance of the drug, the analysis of its active ingredient in formulation is of great importance.
Farnoush Faridbod, Tahereh Jamshidpour, Mohammad Reza Ganjali   +2 more
doaj   +1 more source