Results 81 to 90 of about 3,921,277 (285)

Pramipexole Symmetric and Asymmetric Potentiometric PVC Membrane Sensors

International Journal of Electrochemical Science, 2016
Pramipexole is one of the prescribed medication for Parkinson's disease, which is a dopamine agonist of the non-ergoline class. Due to the importance of the drug, the analysis of its active ingredient in formulation is of great importance.
Farnoush Faridbod, Tahereh Jamshidpour, Mohammad Reza Ganjali   +2 more
doaj   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Diastereomers of Spheroidal Form and Commercially Available Taxifolin Samples

Scientia Pharmaceutica
Taxifolin is a natural polyphenol belonging to the class of flavonoids. The structure of this compound is characterized by the presence of two chiral centers. The spheroidal form of taxifolin (TAXs) has emerged as a promising modification due to enhanced
Roman P. Terekhov, Evgeny S. Melnikov, Ilya D. Nikitin, Margarita A. Tokareva, Tatyana A. Rodina, Anastasiya D. Savina, Denis I. Pankov, Anastasiya K. Zhevlakova, Vladimir L. Beloborodov, Irina A. Selivanova   +9 more
doaj   +1 more source

Large Scale Synthesis of an Ampakine-type Active Pharmaceutical Ingredient Based on a Telescoped Regioselective Double Amidation Reaction

, 2019
This work describes the process development and manufacture of an ampakine-type active pharmaceutical ingredient in clinical trials. A regioselective CDI-mediated amidation process was optimized for the subsequent couplings of two distinctive amines with
Bruno Schiavi (7043300), Julie Hublet (7043288), Christophe Hardouin (2484925), Frédéric Pin (7043279), Jean-François Giffard (7043282), Christine Penloup (7043294), Yvon Hervouet (7043285), Solenn Janvier (7043291), Julien Picard (2468668), Peng Zhang (2071), Xueyan Zhu (1769095), Nathalie Pinault (7043297), Weiwei Zhao (347104)   +12 more
core   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Kinetics of the Solution-Mediated Polymorphic Transformation of the Novel l-Carnitine Orotate Polymorph, Form-II

Pharmaceutics, 2018
Research studies related to the polymorphs of l-Carnitine orotate (CO), a medication used for the treatment and prevention of liver diseases, are insignificant or almost nonexistent.
Ji-Hun An, Wonno Youn, Alice Nguvoko Kiyonga, Changjin Lim, Minho Park, Young-Ger Suh, Hyung Chul Ryu, Jae Sun Kim, Chun-Woong Park, Kiwon Jung   +9 more
doaj   +1 more source

Thin-Film Evaporator Model for Continuous Active Pharmaceutical Ingredient Manufacturing

, 2020
Thin-film evaporator (TFE) is a popular continuous distillation/evaporation technology for pharmaceutical and fine chemical industries and has several equipment and process configurations that make fundamental modeling approaches very challenging ...
Kehua Yin (1915567), Kehua Yin, Kevin Splaine (8368542), Boung Wook Lee (8368539), Brian Roesch, Brian Roesch (8368545), Boung Wook Lee, Kevin Splaine   +7 more
core   +1 more source

Ultrafast visual detection of Streptococcus suis via HtpsC‐targeted LAMP–CRISPR–Cas12a coupled with lateral flow immunochromatography

FEBS Open Bio, EarlyView.
A rapid visual test combines DNA amplification, CRISPR–based target verification, and a lateral flow strip to detect Streptococcus suis. The assay gives results in about 45 min, reduces false‐positive interpretation, and does not require fluorescence equipment.
Liu‐xin Li, Miao Xin, Xiao‐wen Cui, Shi‐yin Yu, Fei Meng, Min Cao, Xiao‐hui Xiong, Yi‐chen Lu   +7 more
wiley   +1 more source

Modification of Ceritinib Crystal Morphology via Spherical Crystallization

Crystals
The formulation process for some drugs can be challenging, due to their unfavorable physical and mechanical properties and poor water solubility. Powder technology has made a significant impact in regard to the modification of the particles in active ...
Iva Zokić, Jasna Prlić Kardum, Lana Crnac, Mirta Sabol, Juraj Vuić, Valentina Travančić   +5 more
doaj   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source