Results 131 to 140 of about 3,928,328 (244)

AI‐Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT Artificial intelligence (AI) is transforming synthetic chemistry from task‐specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed‐loop robotic automation. This review highlights how AI‐assisted planning and robotic execution shorten cycle times, reduce step counts, and improve route ...
Amit Gangwal, Antonio Lavecchia
wiley   +1 more source

DEVELOPMENT OF TECHNOLOGICAL PROCESSES OF THE DRY EXTRACTS OF MORINDA CITRIFOLIA ROOTS

Разработка и регистрация лекарственных средств, 2019
The aim of this study is to develop the technology of dry extracts from the roots of Morinda citrifolia as a prospective phyto-active pharmaceutical ingredient (API) for obtaining medicinal products.
R. K. Agbadi, I. E. Kaukhova, V. A. Vanshtein, S. A. Minina, M. V. Yakovleva, M. A. Vlasenko, A. Y. Kutlushina   +6 more
doaj  

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Efficient Screening of Coformers for Active Pharmaceutical Ingredient Cocrystallization

Controlling the physical properties of solid forms for active pharmaceutical ingredients (APIs) through cocrystallization is an important part of drug product development.
Constantinos C. Pantelides (1356237), Isaac J. Sugden (1356243), Doris E. Braun (1274841), David H. Bowskill (12876145), Claire S. Adjiman (1356249)   +4 more
core   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Real‐Time AI Voice Translation for International Medical Conferences and Beyond: Enabling Multilingual Scientific Exchange

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Language barriers continue to limit participation in international medical communication, and recent advances in artificial intelligence now enable real‐time voice translation to support multilingual scientific exchange. Approach: We describe a demonstration of a bidirectional AI‐mediated voice translation configuration at a ...
Clyde Matava, Benjamin Voit, Achim Schmitz, Thomas Engelhardt   +3 more
wiley   +1 more source

Stability indicating high performance thin layer chromatography method development and validation for quantitative determination of tetracycline hydrochloride in tetracycline hydrochloride active pharmaceutical ingredient (API) and its dosage forms. [PDF]

BMC Chem
Gashaw M, Layloff T, Hymete A, Ashenef A.   +3 more
europepmc   +1 more source

Pesticide use in integrated pest and pollinator management framework to protect pollinator health

Pest Management Science, Volume 81, Issue 4, Page 1691-1696, April 2025.
Integrated pest management (IPM) emphasizes non‐chemical methods, with pesticides as a last resort, while integrated pest and pollinator management (IPPM) integrates pollinator health into pest control strategies. Abstract Agricultural pesticides have historically been a critical tool in controlling pests and diseases, preventing widespread suffering ...
Ngoc T Phan, David J Biddinger, Edwin G Rajotte, Guy Smagghe, Gadi VP Reddy, Zong‐Xin Ren, Neelendra K Joshi   +6 more
wiley   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Apigenin Protects Hypertensive Intracerebral Hemorrhage by Regulating Trx1 Through Binding to PRDX2

Phytotherapy Research, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) remains the most severe stroke subtype with high mortality and disability rates. Although apigenin has shown cerebroprotective potential in preclinical studies, its mechanism of action, particularly in hypertensive ICH, remains poorly understood.
Hao‐chen Xu, Ming Liu, Ying‐ying Sun, Jie‐Dan Ping, Qing‐hua Cui, Jing‐zhou Chen, Hao Li   +6 more
wiley   +1 more source