Results 131 to 140 of about 4,119,069 (249)
Ionic liquid (IL) salt of active pharmaceutical ingredient (API) represents a promising formulation strategy to address low drug solubility and polymorphism prevalent in API solid crystals.
Hadinoto, Kunn, Ng, Liu Han
core +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu +15 more
wiley +1 more source
Pediatric Anesthesia, EarlyView.ABSTRACT Background Language barriers continue to limit participation in international medical communication, and recent advances in artificial intelligence now enable real‐time voice translation to support multilingual scientific exchange. Approach: We describe a demonstration of a bidirectional AI‐mediated voice translation configuration at a ...
Clyde Matava +3 more
wiley +1 more source
Review of Intranasal Active Pharmaceutical Ingredient Delivery Systems
In recent decades, there has been an increased interest in the development of intranasal delivery systems for active pharmaceutical ingredients (APIs) not only for treating local nasal diseases but also for treating systemic diseases, central nervous ...
Ruslan Safarov +4 more
core +1 more source
Pest Management Science, EarlyView.The effect of IRM strategies (rotation, mixture), one additional year under acaricide treatment (Years treated (+1 year)), and one year without acaricide treatment (Years off treatment (+1 year) on mite mortality relative to an approximately 17% baseline.
Sara Bryant, Alexander S Mikheyev
wiley +1 more source
Pest Management Science, EarlyView.Combining intensive drone‐brood removal with brood interruption provided the most effective and consistent seasonal Varroa control. Abstract BACKGROUND Varroa destructor remains the most significant biotic threat to honey bee colonies, and increasing resistance to synthetic acaricides necessitates alternative control strategies.
Leon M. Reinhold, Kirsten S. Traynor
wiley +1 more source
DEVELOPMENT OF TECHNOLOGICAL PROCESSES OF THE DRY EXTRACTS OF MORINDA CITRIFOLIA ROOTS
Разработка и регистрация лекарственных средств, 2019 The aim of this study is to develop the technology of dry extracts from the roots of Morinda citrifolia as a prospective phyto-active pharmaceutical ingredient (API) for obtaining medicinal products.
R. K. Agbadi +6 more
doaj
Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus
Pest Management Science, EarlyView.Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano +7 more
wiley +1 more source
Pest Management Science, EarlyView.Functional screening pipeline of venom peptides from Euscorpius italicus reveal their activity towards globally important pest insects, bacteria, and cells – providing insight on the potential and function of arachnid venom peptides. Abstract BACKGROUND Rising host‐expansion and the global spread of pest insects, confront agricultural sectors with ...
Maurice Pierry +11 more
wiley +1 more source