Results 111 to 120 of about 7,041 (257)

A Comprehensive Study to Compare Different Compound Representations for Predicting Carcinogenicity In Vivo

Journal of Applied Toxicology, EarlyView.
ABSTRACT Carcinogenicity evaluation is a critical component of chemical risk assessment, yet traditional in vivo testing remains time consuming, costly, and ethically challenging. Computational approaches based on machine learning offer promising alternatives, but the relative contributions of different molecular representation strategies for ...
Iuri Barbosa Pereira, Rogerio Salvini, Eloisa Dutra Caldas   +2 more
wiley   +1 more source

Transmission Raman Spectroscopy (TRS) for Accurate Authentication of API in Coated Hydroxychloroquine (HCQ) Tablets

Journal of Raman Spectroscopy, EarlyView.
We report the development and use of a transmission Raman spectroscopy (TRS) system for a more accurate but nonintrusive way of authentication of API in coated HCQ tablets which otherwise is not possible using the backscattered (BS) configuration of Raman spectroscopy. The coating interference is found to be almost zero in case of the TRS and a greater
Vijay Kumar, Khan Mohammad Khan, Hemant Krishna, Khageswar Sahu, Srinibas Satapathy, Shovan Kumar Majumder   +5 more
wiley   +1 more source

Synthesis of valproic acid for medicinal chemistry practical classes

Chemistry Teacher International
Medicinal (or also Pharmaceutical) Chemistry practical classes are intended to familiarize students who have already passed Inorganic and Organic Chemistry Courses in the first or the second year of a Faculty of Pharmacy with real syntheses of medicines ...
Farsa Oldřich
doaj   +1 more source

Use of renewable raw materials in the production of active pharmaceutical ingredients (APIs) [PDF]

2nd European Green Conference (EGC 2024) : Book of Abstracts
Active pharmaceutical ingredients (APIs) constitute a significant and growing market. In recent decades, high production costs as well as stricter environmental regulations in developed countries impose the need to change old synthetic processes and design new ones that are in line with the principles of green chemistry.
Bušić, Valentina, Habuda-Stanić, Mirna, Gašo-Sokač, Dajana   +2 more
openaire  

The effects of royal jelly on human health: A narrative review of clinical studies

JSFA reports, EarlyView.
Abstract Royal jelly (RJ) is a natural bioactive substance with documented effects on human health. This narrative review synthesizes evidence from clinical and clinically relevant experimental studies evaluating the therapeutic potential of RJ.
Georgios Goras, Andreas Thrasyvoulou, Evanthia Tsilimpokou   +2 more
wiley   +1 more source

Mapping the Socialization Externalization Combination Internalization Model's Evolution: A Systematic Literature Review for Future Research

Knowledge and Process Management, EarlyView.
ABSTRACT This systematic literature review examines the evolution and contemporary relevance of the SECI model in knowledge management. A hybrid methodology, combining bibliometric analysis with the TCCM (Theories, Contexts, Characteristics, Methods) framework, was used to provide a comprehensive overview of the research domain.
Ngoc‐Anh Duong, Ryuichi Nakamoto
wiley   +1 more source

Chemical Ionization Mass Spectrometry: Fundamental Principles, Diverse Applications, and the Latest Technological Frontiers

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The review examines the evolution of chemical ionization mass spectrometry (CI‐MS), a technique developed in 1966 by Field and Munson. CI is a soft‐ionization method that produces more intense molecular ions with less fragmentation than electron ionization (EI).
Malvika Dutt, Adriana Arigò, Giorgio Famiglini, Pierangela Palma, Achille Cappiello   +4 more
wiley   +1 more source

AI‐Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT Artificial intelligence (AI) is transforming synthetic chemistry from task‐specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed‐loop robotic automation. This review highlights how AI‐assisted planning and robotic execution shorten cycle times, reduce step counts, and improve route ...
Amit Gangwal, Antonio Lavecchia
wiley   +1 more source

Comparison of Consumer Smartwatch and Research‐Grade Accelerometer‐Derived Step Counts in Amyotrophic Lateral Sclerosis

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Objective, scalable measures of function are needed in amyotrophic lateral sclerosis (ALS). Research‐grade accelerometers are promising but may be difficult to deploy for prolonged remote monitoring, whereas consumer smartwatches offer a practical alternative. We evaluated the feasibility of long‐term smartwatch monitoring in
Gordon Jewett, Reed Ferber, Colin B. Josephson, Lawrence Korngut, Joon Lee   +4 more
wiley   +1 more source

Dose‐dependent efficacy of a novel dsRNA‐based solution containing vadescana for Varroa destructor control

Pest Management Science, EarlyView.
Vadescana is a novel dsRNA‐based product that targets Varroa fecundity. Vadescana applied at 4 g/brood box in one application was most effective at reducing Varroa populations for up to 18 weeks. Abstract BACKGROUND A novel dsRNA‐based product, containing a molecule called vadescana, interferes with Varroa destructor (Anderson and Trueman) fecundity ...
Briana E Price, Ryan Kuesel, Taylor Reams, Brian Manley, James Masucci, Brandon K Hopkins   +5 more
wiley   +1 more source