Results 101 to 110 of about 4,119,069 (249)

Surface analysis of sodium metamizolate as an active pharmaceutical ingredient in solid form [PDF]

This study focuses on the surface and subsurface characterization of a pharmaceutical tablet containing sodium metamizolate (NaMET), with an emphasis on mass spectrometry using time-of-flight secondary ion mass spectrometry (ToF-SIMS).
Finšgar, Matjaž, Varda, Katja Andrina
core   +1 more source

The impact of medication shortages on paediatric care: A retrospective impact analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Medication shortages are a growing global concern, with potentially greater consequences in paediatric patients because of the limited availability of safe, evidence‐based and appropriately formulated medication. This study aimed to evaluate the impact of medication shortages on paediatric patients by assessing the suitability and safety of ...
Maaike Johanna Rutten ‐ van Kranenburg, Laurens Christiaan van Rijn, Elisabeth Johanna Ruijgrok, Sinno Henricus Paulus Simons, Brigitta Carolina Maria Witjes, Jan‐Dietert Christoffer Brugma, Robert Bernard Flint   +6 more
wiley   +1 more source

Fast and Sustainable Active Pharmaceutical Ingredient (API) Screening in Over-the-Counter and Prescription Drug Products by Surface-Assisted Plasma-Based Desorption/Ionization High-Resolution Mass Spectrometry

FAST AND SUSTAINABLE ACTIVE PHARMACEUTICAL INGREDIENT (API) SCREENING IN OVER-THE-COUNTER AND PRESCRIPTION DRUG PRODUCTS BY SURFACE-ASSISTED PLASMA-BASED DESORPTION/IONIZATION HIGH-RESOLUTION MASS SPECTROMETRY Fast and Sustainable Active Pharmaceutical ...
Heide, Maximilian, Engelhard, Carsten, Herrmann, Alexander, Reifenrath, Jonas   +3 more
core  

Safety outcomes of antidiabetic medications: A comprehensive review of the EU summaries of product characteristics and international clinical practice guidelines

British Journal of Clinical Pharmacology, EarlyView.
Aims Information on the safety profile of antidiabetic medications is essential for informed treatment decisions in type 2 diabetes mellitus. Although this information is available in regulatory documents of individual drugs, a comprehensive overview across all approved antidiabetics is lacking.
David Liang, Daniala L. Weir, Safana Thevasahayam, Vera H. M. Deneer, Arno Siebes, Helga Gardarsdottir   +5 more
wiley   +1 more source

Stability-indicating LC method for the quantification of Midazolam active pharmaceutical ingredient and in pharmaceutical formulations [PDF]

, 2018
A stability-indicating LC method was validated for the quantification of midazolam (MDZ) active pharmaceutical ingredient (API) and in pharmaceutical formulations. Isocratic chromatography was performed on C18 column with mobile phase containing methanol/
Grazziotin Rossato-Grando, Luciana, Stulzer, Hellen Karine, Anzilaggo, Daiane, Dallazem Bertol, Charise, Dalla Costa, Bádila Regina   +4 more
core   +2 more sources

Unsupervised machine learning for multi‐system adverse event pattern detection in pharmacovigilance: A proof‐of‐concept analysis of fluoroquinolone reports in FAERS

British Journal of Clinical Pharmacology, EarlyView.
. Aims Traditional pharmacovigilance detects single drug–event associations but cannot readily characterize multi‐system adverse‐event patterns such as fluoroquinolone‐associated disability. We evaluated unsupervised machine learning for this purpose, using fluoroquinolones as an exemplar.
Niaz Chalabianloo, Sheikh S. Abdullah, Kamran Sedig, Flory T. Muanda   +3 more
wiley   +1 more source

Evaluation of Different Types of Paracetamol Active Pharmaceutical Ingredients' Effect on the Release System

Journal of the Turkish Chemical Society, Section A: Chemistry
The primary purpose of this study was to investigate the effect of active pharmaceutical ingredients (APIs) with varying particle sizes and properties on drug release and to develop matrix-type tablets based on poly(acrylic acid sodium salt) (PAANa) with
Şebnem Şenol
doaj   +1 more source

Interval-Partial Least Squares to Eliminate Spectral Moisture Interference in Near Infrared Transmission Quantification of the Active Pharmaceutical Ingredient in Escitalopram Tablets

Near infrared spectroscopy is a technique commonly applied to pharmaceutical tablets to quantify the active pharmaceutical ingredient (API). During its lifetime, the tablet product may absorb water, which can result in deteriorating performance of the ...
Allesø, Morten, Engelsen, Søren B., Warnecke, Solveig, Rinnan, Åsmund   +3 more
core   +1 more source

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

Biotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga, Udisha Singh, Sachin Dattram Pawar   +2 more
wiley   +1 more source

Accelerating green heterocyclic synthesis: Convergence of AI, automation, and sustainable chemistry

Bulletin of the Korean Chemical Society, EarlyView.
Green heterocyclic synthesis and data‐driven tools such as AI, high‐throughput experimentation, continuous flow, and self‐driving laboratories have developed largely in parallel. This review connects them and asks how green metrics such as E‐factor and PMI might serve as explicit optimization targets rather than post‐hoc measures, toward sustainable ...
Noor Aisyah Ahmad Shah, Amirreza Mottafegh, Su‐Hyun Yoo, Jongwoon Kim, Minseon Byeon, Juhwan Noh, Yea‐Lee Lee, Jin Suk Myung, Gwang‐Noh Ahn   +8 more
wiley   +1 more source