Results 81 to 90 of about 4,119,069 (249)

Managing active pharmaceutical ingredient raw material variability during twin-screw blend feeding [PDF]

, 2019
Continuous powder feeding is a critical step in continuous manufacturing of solid dosage forms, as this unit operation should ensure the mass flow consistency at the desired powder feed rate to guarantee the process throughput and final product ...
Pilcer, G, Schubert, MA, De Beer, Thomas, Vervaet, Chris, Vanhoorne, Valérie, Stauffer, Fanny, Chavez, P-F   +6 more
core   +1 more source

A Multimodal Intelligent System for Human Digital Twin Simulation with Continuous Kinematic Data Tracking, Biometric Prognosis, and Cognitive State Feedback in Industrial Environments

Advanced Intelligent Discovery, EarlyView.
This article implements a unified human digital twin framework that integrates cutting edge actuation, sensing, simulation, and bidirectional feedback capability. The approach includes integrating multimodal sensing, AI, and biomechanical simulation into one compact system.
Tajbeed Ahmed Chowdhury, Sebastian Gratz‐Kelly, Eric Wagner, Paul Motzki, Martina Lehser   +4 more
wiley   +1 more source

Evaluation of the Quality Parameters of Anti-flu Combinations Containing Phenylephrine Hydrochloride Available in the Brazilian Market

Orbital: The Electronic Journal of Chemistry
The combination of different active substances in drug products is responsible for optimizing therapies and improving patient adherence. However, the development process of these formulations is highly challenging due to differences in the ...
Diana La Luna Bissetti Costa, Danilo Valsechi Barros, Camila Rosa Moraes Vigna, Victoria Rocha Arriola Carneiro, Everson Willian Fialho Cordeiro, Rodrigo Rotta, Renato Cesar de Souza, Carlos Eduardo Rodrigues Ceroni   +7 more
doaj   +1 more source

The Interoperability Challenge in DFT Workflows Across Implementations

Advanced Intelligent Discovery, EarlyView.
Interoperability and cross‐validation remain major challenges in the computational materials science. In this work, we introduce a common input/output standard that enables internal translation across multiple workflow managers—AiiDA, PerQueue, Pipeline Pilot, and SimStack—while producing results in a unified schema.
Simon K. Steensen, Tushar Singh Thakur, Manuel Dillenz, Johan M. Carlsson, Celso R. C. Rêgo, Eibar Flores, Hamidreza Hajiyani, Felix Hanke, Juan María García Lastra, Wolfgang Wenzel, Nicola Marzari, Tejs Vegge, Giovanni Pizzi, Ivano E. Castelli   +13 more
wiley   +1 more source

Excipients used in nano-technology assisted drug delivery systems

Journal of Excipients and Food Chemicals, 2016
The overall therapeutic benefit of an active pharmaceutical ingredient (API) is dependent on its potency and efficacy to deliver to the site of action.
Arvind Kumar Bansal
doaj  

Determination of the shelf life of the API morpholinium 2-((4-(2-methoxyphenyl)-5-(4-pyridyl)-4H-1,2,4-triazol-3-yl)thio)acetate

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
This study determined the shelf life of the active pharmaceutical ingredient (API) morpholinium 2-(4-(2-methoxyphenyl)-5-(4-pyridyl)-4H-1,2,4-triazol-3-yl)thio)acetate by determining its quantitative storage characteristics. Aim.
A. H. Kaplaushenko, S. O. Vasyuk, A. I. Avramenko , M. Zh. Koichev   +3 more
doaj   +1 more source

Autonomous AI‐Driven Design for Skin Product Formulations

Advanced Intelligent Discovery, EarlyView.
This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang, Yongrui Xiao, Chunlin Chen, Dimitrios Tsaoulidis, Kai Yang, Tao Chen   +5 more
wiley   +1 more source

Polybenzimidazole for Active Pharmaceutical Ingredient Purification: The Mometasone Furoate Case Study

, 2019
Active pharmaceutical ingredient (API) purity is of major concern for pharmaceutical companies and the medical community. Reaching ultralow limits of genotoxic impurities (GTIs), imposed by strict legislation, is often time consuming and economically ...
Frederico Castelo Ferreira, Flávio Alves Ferreira (6797291), João Bandarra, Marta P. Carrasco, Carlos A. M. Afonso, João Bandarra (6797297), Carlos A. M. Afonso (1490650), Teresa Esteves (3329772), Teresa Esteves, Marta P. Carrasco (6797294), Frederico Castelo Ferreira (1543342), Flávio Alves Ferreira   +11 more
core   +1 more source

Integration of Active Pharmaceutical Ingredient production into a pharmaceutical Lean Learning Factory

, 2022
S.245-250In the context of the implementation of Lean Production Systems, companies have become significantly more aware of the need for employee qualification and motivation.
Sieckmann, F., Petrusch, N., Kohl, H., Menn, J.P.   +3 more
core   +1 more source

Hydration Behavior of Tricalcium Silicate in Seawater Relevant Salt Systems: A Hybrid Study with the Aid of Machine Learning

Advanced Intelligent Discovery, EarlyView.
The hydration behavior of C3S in seawater‐relevant solutions is studied based on experiments, boundary nucleation and growth (BNG) modeling, and machine learning. The main ions included in seawater modify hydration mechanisms, with MgCl2 showing the strongest acceleration effect at the same concentration.
Yanjie Sun, Chen Zhang, Ting Zhang, Mengze Hong, Peiliang Shen, Chi Sun Poon, Gang Li   +6 more
wiley   +1 more source