Results 71 to 80 of about 4,119,069 (249)

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

Advanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo, Katie Shi, Lina Kafadarian, Alexandra Bermudez, Johnny Diaz, Liam Edwards, Yunqi Hong, Ziyi Chen, Hyeonji Hwang, Weihong Yan, Alan Levinson, Robert Damoiseaux, Cho‐Jui Hsieh, Tanya Stoyanova, Andrew S. Goldstein, Neil Y.C. Lin   +15 more
wiley   +1 more source

Efficacy and Safety of Dual Paclitaxel and Sirolimus Nanoparticle-Coated Balloon

JACC: Basic to Translational Science
Summary: We evaluated a novel dual active pharmaceutical ingredient (API) drug-coated balloon (DCB), which consists of a coating of nanoparticles encapsulating low-dose paclitaxel (PTX) in combination with sirolimus in a synergistic ratio.
Kenji Kawai, MD, Mohammed Tanjimur Rahman, PhD, Ryan Nowicki, BS, Frank D. Kolodgie, PhD, Atsushi Sakamoto, MD, Rika Kawakami, MD, Takao Konishi, MD, Renu Virmani, MD, Vinod Labhasetwar, PhD, Aloke V. Finn, MD   +9 more
doaj   +1 more source

Photoelectrocatalytic Diazidation of Olefins via Synergistic Dual Iron Species

Advanced Science, EarlyView.
We report a simple and general approach for 1,2‐diazidation of alkenes by a photoelectrochemical strategy using TMSN3 as an azide source. This transformation proceeds using earth‐abundant iron under mild reaction conditions. It displays broad functional group compatibility and accommodates diverse alkene types‐including unactivated, activated, electron‐
Zhi‐Peng Guan, Zhong‐Qi Yi, Ning Li, He‐Yi Li, Jun Yao, Hong‐Gui Huang, Zhi‐Bing Dong   +6 more
wiley   +1 more source

A computational study of Ising‐based solvers for discrete landscape exploration in process optimization

AIChE Journal, EarlyView.
ABSTRACT Conceptual process design combines discrete configuration choices with continuous operating decisions, often yielding difficult mixed‐integer nonlinear or simulation‐based optimization problems. This work presents an exploratory computational assessment of Ising‐based solvers, simulated annealing, quantum annealing, and entropy computing, as ...
Yirang Park, David E. Bernal Neira
wiley   +1 more source

CO-CRYSTALS OF ACTIVE PHARMACEUTICAL INGREDIENT-IBUPROFEN LYSINE [PDF]

, 2020
Objective: Co-crystal is defined as a crystalline complex of two or more neutral molecules bound together primarily by hydrogen bonding or other non-covalent interactions.
KULKARNI, ALPANA, BACHHAV, RITESH, HOL, VISHAL, SHETE, SWAPNIL   +3 more
core   +1 more source

Machine learning driven many‐objective moving horizon scheduling optimization

AIChE Journal, EarlyView.
Abstract Industrial electrification can decarbonize chemical manufacturing, but it exposes operations to volatile electricity prices and carbon intensities. This work develops a machine learning‐enhanced many‐objective moving horizon scheduling framework that predicts objective correlation groupings from 48‐hour price and emission‐intensity profiles ...
Hongxuan Wang, Andrew Allman
wiley   +1 more source

A REVIEW ON SUPRAMOLECULAR CHEMISTRY IN DRUG DESIGN AND FORMULATION RESEARCH [PDF]

, 2013
Supramolecular chemistry, other way called as intermolecular chemistry disclose the relationship of molecules with environment. It exploits while exposing the physicochemical phenomina that happens when two like or unlike molecules/ions/systems contact ...
Divya, D.; Pharmaceutical Chemistry GITAM Institute of Pharmacy, GITAM University, Vishakapatnam- 530045, AP, India, Anbazhagan, S.; Karuna College of Pharmacy, Thirumittacode, Palakad-679533, Kerala, India, Padmini, D.; Pharmaceutical Chemistry GITAM Institute of Pharmacy, GITAM University, Vishakapatnam- 530045, AP, India, Vepuri, Suresh B; Pharmaceutical Chemistry GITAM Institute of Pharmacy, GITAM University, Vishakapatnam- 530045, AP, India   +3 more
core   +1 more source

Data‐Guided Photocatalysis: Supervised Machine Learning in Water Splitting and CO2 Conversion

Advanced Intelligent Discovery, EarlyView.
This review highlights recent advances in supervised machine learning (ML) for photocatalysis, emphasizing methods to optimize photocatalyst properties and design materials for solar‐driven water splitting and CO2 reduction. Key applications, challenges, and future directions are discussed, offering a practical framework for integrating ML into the ...
Paul Rossener Regonia, Christian Mark Pelicano   +1 more
wiley   +1 more source

Analytical method (HPLC), validation used for identification and assay of the pharmaceutical active ingredient, Tylosin tartrate for veterinary use and its finite product Tilodem 50, hydrosoluble powder [PDF]

Medicamentul Veterinar, 2010
In SC DELOS IMPEX ’96 SRL the quality of the active pharmaceutical ingredient (API) for the finite product Tilodem 50 - hydrosoluble powder was acomkplished in the respect of last European Pharmacopoeia.The method for analysis used in this purpose was ...
Maria Neagu
doaj  

Prednisone raw material characterization and formulation development

Brazilian Journal of Pharmaceutical Sciences, 2018
Solid dosage forms for oral use, particularly tablets, are the most highly used dosage forms in therapy because they are easily administered, have high productivity and relatively low cost and provide a more stable drug to form a semi-solid net. Numerous
Leonardo Henrique Toehwé, Livia Deris Prado, Helvécio Vinícius Antunes Rocha   +2 more
doaj   +1 more source