Results 61 to 70 of about 3,928,328 (244)

Crystallization process development of an active pharmaceutical ingredient

, 2021
Kristalizacija ima široku primjenu u farmaceutskoj i kemijskoj industriji kao jedna od najjednostavnijih i najjeftinijih metoda dobivanja čvrstih tvari visoke čistoće.
Topalović, Lana
core   +3 more sources

Counterfeit and Substandard Test of the Antimalarial Tablet Riamet^® by Means of Raman Hyperspectral Multicomponent Analysis

Molecules, 2019
The fight against counterfeit pharmaceuticals is a global issue of utmost importance, as failed medication results in millions of deaths every year. Particularly affected are antimalarial tablets.
Timea Frosch, Elisabeth Wyrwich, Di Yan, Christian Domes, Robert Domes, Juergen Popp, Torsten Frosch   +6 more
doaj   +1 more source

Similarity‐Enhanced Representation Learning of Non‐Canonical Amino Acids for Therapeutic Peptide Modeling

Advanced Science, EarlyView.
Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu, Lesong Wei, Jianmin Wang, Yuanpeng Xiong, Ruochi Zhang, Yu Wang, Chao Zha, Qiangcheng Zeng, Xin Gao   +8 more
wiley   +1 more source

Review of Intranasal Active Pharmaceutical Ingredient Delivery Systems

In recent decades, there has been an increased interest in the development of intranasal delivery systems for active pharmaceutical ingredients (APIs) not only for treating local nasal diseases but also for treating systemic diseases, central nervous ...
Ruslan Safarov, Mariia Gordienko, Natalia Menshutina, Olga Fedotova, Anastasia Uvarova   +4 more
core   +1 more source

A computational study of Ising‐based solvers for discrete landscape exploration in process optimization

AIChE Journal, EarlyView.
ABSTRACT Conceptual process design combines discrete configuration choices with continuous operating decisions, often yielding difficult mixed‐integer nonlinear or simulation‐based optimization problems. This work presents an exploratory computational assessment of Ising‐based solvers, simulated annealing, quantum annealing, and entropy computing, as ...
Yirang Park, David E. Bernal Neira
wiley   +1 more source

Practical Computational Exploration of Chemical Reaction Space: Assessing the Chemical Stability of Active Pharmaceutical Ingredients Under Acidic Conditions

Angewandte Chemie, EarlyView.
Metadynamics simulations drive automated reaction exploration of acid‐catalysed drug degradation, generating a network spanning 1720 species and 2471 elementary steps. QM‐based filtering reduces the network to eight candidate pathways for rigorous DFT refinement and microkinetic modelling.
Julius Seumer, Maria Harris Rasmussen, Oriana Brea, Mikko Muuronen, Andreas H. Göller, Jan H. Jensen   +5 more
wiley   +2 more sources

Efficient Screening of Coformers for Active Pharmaceutical Ingredient Cocrystallization

, 2022
[Image: see text] Controlling the physical properties of solid forms for active pharmaceutical ingredients (APIs) through cocrystallization is an important part of drug product development.
Constantinos C. Pantelides, Braun, Doris E, Bowskill, David H., Bowskill, David H, Isaac J. Sugden, Pantelides, Constantinos C., Claire S. Adjiman, Adjiman, Claire S, Sugden, Isaac J, Doris E. Braun, Braun, Doris E., Sugden, Isaac J., David H. Bowskill, Pantelides, Constantinos C, Adjiman, Claire S.   +14 more
core   +1 more source

Machine learning driven many‐objective moving horizon scheduling optimization

AIChE Journal, EarlyView.
Abstract Industrial electrification can decarbonize chemical manufacturing, but it exposes operations to volatile electricity prices and carbon intensities. This work develops a machine learning‐enhanced many‐objective moving horizon scheduling framework that predicts objective correlation groupings from 48‐hour price and emission‐intensity profiles ...
Hongxuan Wang, Andrew Allman
wiley   +1 more source

Efficacy and Safety of Dual Paclitaxel and Sirolimus Nanoparticle-Coated Balloon

JACC: Basic to Translational Science
Summary: We evaluated a novel dual active pharmaceutical ingredient (API) drug-coated balloon (DCB), which consists of a coating of nanoparticles encapsulating low-dose paclitaxel (PTX) in combination with sirolimus in a synergistic ratio.
Kenji Kawai, MD, Mohammed Tanjimur Rahman, PhD, Ryan Nowicki, BS, Frank D. Kolodgie, PhD, Atsushi Sakamoto, MD, Rika Kawakami, MD, Takao Konishi, MD, Renu Virmani, MD, Vinod Labhasetwar, PhD, Aloke V. Finn, MD   +9 more
doaj   +1 more source

Mathematical modeling of injury healing process under the action of an active pharmaceutical ingredient (API)

Selecciones Matemáticas, 2019
In this work we carried out the mathematical modeling of the wound healing process, which is a well documented topic in medical and biological practice; but mathematically speaking there are still too much to be done for a clear understanding of the ...
Alfredo Palomino I., Leighton Estrada R., Javier Valeriano M., Sergio Luque M.   +3 more
doaj   +1 more source