Tregitope Peptides: The Active Pharmaceutical Ingredient of IVIG? [PDF]
Clinical and Developmental Immunology, 2013 Five years ago, we reported the identification and characterization of several regulatory T-cell epitopes (now called Tregitopes) that were discovered in the heavy and light chains of IgG (De Groot et al. Blood, 2008).
Anne S. De Groot +3 more
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Structure of the active pharmaceutical ingredient bismuth subsalicylate [PDF]
Nature Communications, 2022 Pepto-Bismol has been used to treat gastrointestinal disorders for over a century, yet the structure of its active ingredient is still under debate. Here, the authors apply electron crystallography to unveil the structure of bismuth subsalicylate.
Erik Svensson Grape +4 more
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Review of Intranasal Active Pharmaceutical Ingredient Delivery Systems [PDF]
PharmaceuticalsIn recent decades, there has been an increased interest in the development of intranasal delivery systems for active pharmaceutical ingredients (APIs) not only for treating local nasal diseases but also for treating systemic diseases, central nervous ...
Ruslan Safarov +4 more
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(1R,3S)-3-(1H-Benzo[d]imidazol-2-yl)-1,2,2-trimethylcyclopentane-1-carboxylic acid as a new anti-diabetic active pharmaceutical ingredient [PDF]
Acta Crystallographica Section E: Crystallographic Communications, 2020 The chiral title compound, C16H20N2O2, which can be used for producing active pharmaceutical ingredients for treatment of type 2 pancreatic diabetes and other pathologies dependent on insulin resistance, was prepared from (1R,3S)-camphoric acid and o ...
Sergiy M. Kovalenko +4 more
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Open-source Raman spectra of chemical compounds for active pharmaceutical ingredient development [PDF]
Scientific DataRaman spectroscopy is utilised extensively in pharmaceutical analysis for tasks such as drug discovery, quality control and active pharmaceutical ingredient (API) development.
Aaron R. Flanagan, Frank G. Glavin
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Crystal structure of pirfenidone (5-methyl-1-phenyl-1H-pyridin-2-one): an active pharmaceutical ingredient (API) [PDF]
Acta Crystallographica Section E: Crystallographic Communications, 2019 The crystal structure of pirfenidone, C12H11NO [alternative name: 5-methyl-1-phenylpyridin-2(1H)-one], an active pharmaceutical ingredient (API) approved in Europe and Japan for the treatment of Idiopathic pulmonary fibrosis (IPF), is reported here for ...
Mauro Barbero +4 more
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Promoting local production and active pharmaceutical ingredient (API) industry in low and middle income countries (LMICs): impact on medicines access and policy [PDF]
Journal of Pharmaceutical Policy and PracticeThe success of universal coverage depends on ensuring that patients have access to medicine. Encouraging local production of medicines in developing countries can provide better access to medicines.
Muhammad Akhtar Abbas Khan, Asim Rauf
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Safer Solvents for Active Pharmaceutical Ingredient Purification Using Column Chromatography [PDF]
ACS Environmental AuChristian Ayafor +4 more
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Interactions and incompatibilities between the active ingredient and the excipient [PDF]
Farmacja Polska, 2021 Excipients are important components of the final medicinal product. They perform many important functions as fillers, lubricants, disintegrating agents, stabilizers, emulsifiers, etc., and their presence in the formulation is essential.
Ewelina Mundzik-Janczarska +1 more
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Ionic Liquids as Active Pharmaceutical Ingredients [PDF]
ChemMedChem, 2011 AbstractIonic liquids (ILs) are ionic compounds that possess a melting temperature below 100 °C. Their physical and chemical properties are attractive for various applications. Several organic materials that are now classified as ionic liquids were described as far back as the mid‐19th century.
Ferraz, Ricardo +4 more
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