Structure of the active pharmaceutical ingredient bismuth subsalicylate [PDF]
Nature Communications, 2022 Pepto-Bismol has been used to treat gastrointestinal disorders for over a century, yet the structure of its active ingredient is still under debate. Here, the authors apply electron crystallography to unveil the structure of bismuth subsalicylate.
Erik Svensson Grape +4 more
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Review of Intranasal Active Pharmaceutical Ingredient Delivery Systems [PDF]
PharmaceuticalsIn recent decades, there has been an increased interest in the development of intranasal delivery systems for active pharmaceutical ingredients (APIs) not only for treating local nasal diseases but also for treating systemic diseases, central nervous ...
Ruslan Safarov +4 more
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Open-source Raman spectra of chemical compounds for active pharmaceutical ingredient development [PDF]
Scientific DataRaman spectroscopy is utilised extensively in pharmaceutical analysis for tasks such as drug discovery, quality control and active pharmaceutical ingredient (API) development.
Aaron R. Flanagan, Frank G. Glavin
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Agglomeration Control during Ultrasonic Crystallization of an Active Pharmaceutical Ingredient
Crystals, 2017 Application of ultrasound during crystallization can efficiently inhibit agglomeration. However, the mechanism is unclear and sonication is usually enabled throughout the entire process, which increases the energy demand. Additionally, improper operation
Bjorn Gielen +4 more
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Tregitope Peptides: The Active Pharmaceutical Ingredient of IVIG? [PDF]
Clinical and Developmental Immunology, 2013 Five years ago, we reported the identification and characterization of several regulatory T-cell epitopes (now called Tregitopes) that were discovered in the heavy and light chains of IgG (De Groot et al. Blood, 2008).
Anne S. De Groot +3 more
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Crystal structure of pirfenidone (5-methyl-1-phenyl-1H-pyridin-2-one): an active pharmaceutical ingredient (API) [PDF]
Acta Crystallographica Section E: Crystallographic Communications, 2019 The crystal structure of pirfenidone, C12H11NO [alternative name: 5-methyl-1-phenylpyridin-2(1H)-one], an active pharmaceutical ingredient (API) approved in Europe and Japan for the treatment of Idiopathic pulmonary fibrosis (IPF), is reported here for ...
Mauro Barbero +4 more
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Promoting local production and active pharmaceutical ingredient (API) industry in low and middle income countries (LMICs): impact on medicines access and policy [PDF]
Journal of Pharmaceutical Policy and PracticeThe success of universal coverage depends on ensuring that patients have access to medicine. Encouraging local production of medicines in developing countries can provide better access to medicines.
Muhammad Akhtar Abbas Khan, Asim Rauf
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Safer Solvents for Active Pharmaceutical Ingredient Purification Using Column Chromatography [PDF]
ACS Environmental AuChristian Ayafor +4 more
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Interactions and incompatibilities between the active ingredient and the excipient [PDF]
Farmacja Polska, 2021 Excipients are important components of the final medicinal product. They perform many important functions as fillers, lubricants, disintegrating agents, stabilizers, emulsifiers, etc., and their presence in the formulation is essential.
Ewelina Mundzik-Janczarska +1 more
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Continuous Flow Synthesis of Propofol
Molecules, 2021 Herein, we report a continuous flow process for the synthesis of 2,6-diisopropylphenol—also known as Propofol—a short-acting intravenous anesthesia, widely used in intensive care medicine to provide sedation and hypnosis.
Romain Mougeot +3 more
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