Results 31 to 40 of about 3,921,277 (285)

Crystal Structure and Solid-State Conformational Analysis of Active Pharmaceutical Ingredient Venetoclax

Crystals, 2021
Venetoclax is an orally bioavailable, B-cell lymphoma-2 selective inhibitor used for the treatment of chronic lymphocytic leukemia, small lymphocytic lymphoma, and acute myeloid leukemia.
Franc Perdih, Nina Žigart, Zdenko Časar   +2 more
doaj   +1 more source

Characterization of the conglomerate form of acetyl-dl-leucine by thermal analysis and solubility measurements [PDF]

, 2012
Starting from a mixture of enantiomers in solution, crystallization can generate different types of crystals. In order to determine which type of crystal is obtained in the case of acetylleucine, an active pharmaceutical ingredient (API), analytical ...
B. Biscans, Pena, Richard, S. Teychené, Estime, Nicolas, Biscans, Béatrice, R. Pena, N. Estime, Teychené, Sébastien, Autret, Jean Marie, J.M. Autret   +9 more
core   +1 more source

Development and validation of alternative methods by non-aqueous acid-base titration and derivative ultraviolet spectrophotometry for quantification of sildenafil in raw material and tablets

Brazilian Journal of Pharmaceutical Sciences, 2017
Sildenafil citrate (SILC) is a potent phosphodiesterase-5 inhibitor used for erectile dysfunction and pulmonary hypertension. This study shows two simple, fast and alternative analytical methods for SILC determination by non-aqueous titration and by ...
Taízia Dutra Silva, Cibele Rodrigues Toledo, Cristina Duarte Vianna-Soares   +2 more
doaj   +1 more source

A Novel Formulation of Fosamprenavir Calcium: Therapeutic Deep Eutectic Solvent with Enhanced Properties

Crystals
In the pharmaceutical industry, deep eutectic solvents can be used to enhance the solubility, permeability, and absorption of active pharmaceutical ingredients.
Jasna Prlić Kardum, Iva Zokić, Aleksandra Sander, Patricija Pelin   +3 more
doaj   +1 more source

Agglomeration Control during Ultrasonic Crystallization of an Active Pharmaceutical Ingredient

Crystals, 2017
Application of ultrasound during crystallization can efficiently inhibit agglomeration. However, the mechanism is unclear and sonication is usually enabled throughout the entire process, which increases the energy demand. Additionally, improper operation
Bjorn Gielen, Jeroen Jordens, Leen C. J. Thomassen, Leen Braeken, Tom Van Gerven   +4 more
doaj   +1 more source

Distinguishing anhydrous and hydrous forms of an active pharmaceutical ingredient in a tablet formulation using solid-state NMR spectroscopy

, 2007
With or without water? In under two hours, an NMR spectroscopy experiment can determine whether the anhydrous form of an active pharmaceutical ingredient is present in a tablet formulation.
Steven P. Brown, Brown, Steven P., John M. Griffin, Griffin, John M., Martin, Dave R., Dave R. Martin   +5 more
core   +4 more sources

Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications

Acta Pharmaceutica Sinica B, 2021
Pharmaceutical cocrystals are multicomponent systems in which at least one component is an active pharmaceutical ingredient and the others are pharmaceutically acceptable ingredients.
Minshan Guo, Xiaojie Sun, Jiahui Chen, Ting Cai   +3 more
doaj   +1 more source

Dissolution of the active pharmaceutical ingredient determined for each sample.

, 2018
Dissolution of the active pharmaceutical ingredient determined for each sample.
Emmanuel Wemakor (6029687), Cathrin Hauk (6029690), Lutz Heide (194238), Simon Schäfermann (6029684)   +3 more
core   +1 more source

Content of the active pharmaceutical ingredient determined for each sample.

, 2018
Content of the active pharmaceutical ingredient determined for each sample.
Emmanuel Wemakor (6029687), Cathrin Hauk (6029690), Lutz Heide (194238), Simon Schäfermann (6029684)   +3 more
core   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source