Advanced flow cell design for in vitro release testing of mucoadhesive buccal films
Acta Pharmaceutica, 2020 Films for buccal application are a slowly emerging new platform for drug delivery. There remains a lack of analytical techniques for the determination of in vitro active pharmaceutical ingredient release. The aim here was to develop an alternative method
Grilc Blaž +2 more
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Determination of active pharmaceutical ingredient – chloropyramine in dragées [PDF]
, 2015 Chloropyramine is a first generation antihistamine drug approved in some Eastern European countries for the treatment of allergic conjunctivitis, allergic rhinitis, bronchial asthma, and other allergic conditions. Chloropyramine is known as a competitive
Gjorgjeska, Biljana +2 more
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Pharmaceutics, 2020 Pharmaceutical eutectics are solid mixtures, where the crystals of active pharmaceutical ingredients (APIs) are finely divided in the phase-separated microstructures.
Songhee Jin +3 more
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IUCrData, 2017 In the title compound, C15H20N7O3S+·CH3O3S− (CH5132799 mesylate), two molecular entities form a salt with proton transfer from methanesulfonic acid to the aminopyrimidine moiety of CH5132799.
Masahide Aoki +5 more
doaj +1 more source
Eutectic Formation of Naproxen with Some Dicarboxylic Acids
Pharmaceutics, 2021 Eutectic formation with additives is one of the established methods to improve the dissolution behaviors of active pharmaceutic ingredients (APIs). The improvement is mainly due to the increase in the surface area for dissolution, which originates from ...
Dahye Kim, Soeun Jang, Il Won Kim
doaj +1 more source
Crystallization Behavior of Ceritinib: Characterization and Optimization Strategies
ChemEngineering, 2023 Because of the specific thermodynamic properties of active pharmaceutical ingredients, the process of crystallization often meets implementation challenges in the pharmaceutical industry.
Iva Zokić, Jasna Prlić Kardum
doaj +1 more source
Computer-Aided Retrosynthesis for Greener and Optimal Total Synthesis of a Helicase-Primase Inhibitor Active Pharmaceutical Ingredient. [PDF]
JACS AuThis study explores the application of computer-aided retrosynthesis (CAR) for developing greener and more efficient synthetic routes for the active pharmaceutical ingredient (API) IM-204, a helicase primase inhibitor with potential against Herpes ...
Teixeira RI +3 more
europepmc +3 more sources
Influence of pH, Temperature and Impurities on the Solubility of an Active Pharmaceutical Ingredient (API) [PDF]
, 2010 Solubility, which defines the liquid /solid equilibrium, is a key parameter to control a crystallization process. This work is focused on the effects of pH, temperature and impurities on the aqueous solubility of an Active Pharmaceutical Ingredient (API).
Estime, Nicolas +7 more
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Method of the Metronidazole and Clotrimazole administration in the content of the emulsion basis
Zaporožskij Medicinskij Žurnal, 2013 Proved optimum method of administration of active pharmaceutical ingredients – metronidazole and clotrimazole – in the emulsion base of ointment as a suspension with vaseline oil.
V. V. Rudenko, S. V. Biryukova
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Light-sensitive medicinal compounds – the actual review of studies and strategies in proceedings [PDF]
Farmacja Polska, 2019 The main procedure for stability testing of Active Pharmaceutical Ingredients (API) and medicinal products is described in the guidelines of the International Council for the Harmonization of Technical Requirements for Human Drugs (ICH).
Marzena Jamrógiewicz +2 more
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