Results 21 to 30 of about 3,741,697 (242)

Advanced flow cell design for in vitro release testing of mucoadhesive buccal films

Acta Pharmaceutica, 2020
Films for buccal application are a slowly emerging new platform for drug delivery. There remains a lack of analytical techniques for the determination of in vitro active pharmaceutical ingredient release. The aim here was to develop an alternative method
Grilc Blaž, Zdovc Jurij, Planinšek Odon   +2 more
doaj   +1 more source

Binary Mixtures of Some Active Pharmaceutical Ingredients with Fatty Alcohols—The Criteria of Successful Eutectic Formation and Dissolution Improvement

Pharmaceutics, 2020
Pharmaceutical eutectics are solid mixtures, where the crystals of active pharmaceutical ingredients (APIs) are finely divided in the phase-separated microstructures.
Songhee Jin, Jisun Jang, Soyeon Lee, Il Won Kim   +3 more
doaj   +1 more source

5-(7-Methanesulfonyl-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-ylamine mesylate

IUCrData, 2017
In the title compound, C15H20N7O3S+·CH3O3S− (CH5132799 mesylate), two molecular entities form a salt with proton transfer from methanesulfonic acid to the aminopyrimidine moiety of CH5132799.
Masahide Aoki, Takahiro Ichige, Junichi Shiina, Satoshi Tanida, Koji Shiraki, Masaki Ishigai   +5 more
doaj   +1 more source

Eutectic Formation of Naproxen with Some Dicarboxylic Acids

Pharmaceutics, 2021
Eutectic formation with additives is one of the established methods to improve the dissolution behaviors of active pharmaceutic ingredients (APIs). The improvement is mainly due to the increase in the surface area for dissolution, which originates from ...
Dahye Kim, Soeun Jang, Il Won Kim
doaj   +1 more source

Results for samples with intra-batch variation: Active pharmaceutical ingredient, pH and retention status.

, 2021
Results for samples with intra-batch variation: Active pharmaceutical ingredient, pH and retention status.
Joyce M. Ondicho (11467141), Lucia K. Keter (11467144), Lilian C. Koech (11467138), Beatrice Njeri Irungu (11467135)   +3 more
core   +1 more source

Crystallization Behavior of Ceritinib: Characterization and Optimization Strategies

ChemEngineering, 2023
Because of the specific thermodynamic properties of active pharmaceutical ingredients, the process of crystallization often meets implementation challenges in the pharmaceutical industry.
Iva Zokić, Jasna Prlić Kardum
doaj   +1 more source

Influence of pH, Temperature and Impurities on the Solubility of an Active Pharmaceutical Ingredient (API) [PDF]

, 2010
Solubility, which defines the liquid /solid equilibrium, is a key parameter to control a crystallization process. This work is focused on the effects of pH, temperature and impurities on the aqueous solubility of an Active Pharmaceutical Ingredient (API).
Estime, Nicolas, Biscans, Béatrice, Teychené, Sébastien, Autret, Jean Marie   +3 more
core   +1 more source

Thermal Stability and Kinetics of Degradation of Moxonidine as Pure Ingredient vs. Pharmaceutical Formulation

, 2023
The stability of active pharmaceutical ingredients (APIs) and the corresponding pharmaceutical formulations are nowadays of great importance in pharmaceutical research and technology. The quality of an API or of finished pharmaceutical products (FPPs) is
Bianca Baul, Ionuţ Ledeţi, Titus Vlase, Francisc Peter, Denisa Cîrcioban, Amalia Ridichie, Adriana Ledeţi, Gabriela Vlase   +7 more
core   +1 more source

Crystal Structure and Solid-State Conformational Analysis of Active Pharmaceutical Ingredient Venetoclax

Crystals, 2021
Venetoclax is an orally bioavailable, B-cell lymphoma-2 selective inhibitor used for the treatment of chronic lymphocytic leukemia, small lymphocytic lymphoma, and acute myeloid leukemia.
Franc Perdih, Nina Žigart, Zdenko Časar   +2 more
doaj   +1 more source

Characterization of the conglomerate form of acetyl-dl-leucine by thermal analysis and solubility measurements [PDF]

, 2012
Starting from a mixture of enantiomers in solution, crystallization can generate different types of crystals. In order to determine which type of crystal is obtained in the case of acetylleucine, an active pharmaceutical ingredient (API), analytical ...
B. Biscans, Pena, Richard, S. Teychené, Estime, Nicolas, Biscans, Béatrice, R. Pena, N. Estime, Teychené, Sébastien, Autret, Jean Marie, J.M. Autret   +9 more
core   +1 more source