Results 11 to 20 of about 41,601 (250)

Continuous Flow Synthesis of Propofol

Molecules, 2021
Herein, we report a continuous flow process for the synthesis of 2,6-diisopropylphenol—also known as Propofol—a short-acting intravenous anesthesia, widely used in intensive care medicine to provide sedation and hypnosis.
Romain Mougeot, Philippe Jubault, Julien Legros, Thomas Poisson   +3 more
doaj   +1 more source

STABILITY-INDICATING LC METHOD FOR THE QUANTIFICATION OF MIDAZOLAM ACTIVE PHARMACEUTICAL INGREDIENT AND IN PHARMACEUTICAL FORMULATIONS

Drug Analytical Research, 2018
A stability-indicating LC method was validated for the quantification of midazolam (MDZ) active pharmaceutical ingredient (API) and in pharmaceutical formulations. Isocratic chromatography was performed on C18 column with mobile phase containing methanol/
Daiane Anzilaggo, Bádila Regina Dalla Costa, Luciana Grazziotin Rossato-Grando, Hellen Karine Stulzer, Charise Dallazem Bertol   +4 more
doaj   +9 more sources

Enhanced Dissolution of Naproxen by Combining Cocrystallization and Eutectic Formation

Pharmaceutics, 2021
Improving dissolution properties of active pharmaceutical ingredients (APIs) is a critical step in drug development with the increasing occurrence of sparingly soluble APIs.
Hakyeong Kim, Soeun Jang, Il Won Kim
doaj   +1 more source

Brazilian national production of active pharmaceutical ingredients: regulatory and strategic framework

Anais da Academia Brasileira de Ciências, 2023
Active Pharmaceutical Ingredient (API) is any component of the final pharmaceutical product that serves as the active ingredient. The goal of the API Manufacturing is to produce APIs that are competitively priced and meet the quality standards with the ...
MARLON DANIEL L. TONINI, RAQUEL O. LOPES, MARIA LETÍCIA C. BARBOSA   +2 more
doaj   +1 more source

Advanced flow cell design for in vitro release testing of mucoadhesive buccal films

Acta Pharmaceutica, 2020
Films for buccal application are a slowly emerging new platform for drug delivery. There remains a lack of analytical techniques for the determination of in vitro active pharmaceutical ingredient release. The aim here was to develop an alternative method
Grilc Blaž, Zdovc Jurij, Planinšek Odon   +2 more
doaj   +1 more source

Binary Mixtures of Some Active Pharmaceutical Ingredients with Fatty Alcohols—The Criteria of Successful Eutectic Formation and Dissolution Improvement

Pharmaceutics, 2020
Pharmaceutical eutectics are solid mixtures, where the crystals of active pharmaceutical ingredients (APIs) are finely divided in the phase-separated microstructures.
Songhee Jin, Jisun Jang, Soyeon Lee, Il Won Kim   +3 more
doaj   +1 more source

Batch Crystallization of Active Pharmaceutical Ingredient: Kinetics and Equilibrium Modelling [PDF]

Kemija u Industriji, 2018
Development of a mathematical model for batch crystallization of fesoterodine fumarate, an active pharmaceutical ingredient, in 2-butanone is presented.
Marko Trampuž, Dušan Teslić, Blaž Likozar   +2 more
doaj   +1 more source

5-(7-Methanesulfonyl-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-ylamine mesylate

IUCrData, 2017
In the title compound, C15H20N7O3S+·CH3O3S− (CH5132799 mesylate), two molecular entities form a salt with proton transfer from methanesulfonic acid to the aminopyrimidine moiety of CH5132799.
Masahide Aoki, Takahiro Ichige, Junichi Shiina, Satoshi Tanida, Koji Shiraki, Masaki Ishigai   +5 more
doaj   +1 more source

Eutectic Formation of Naproxen with Some Dicarboxylic Acids

Pharmaceutics, 2021
Eutectic formation with additives is one of the established methods to improve the dissolution behaviors of active pharmaceutic ingredients (APIs). The improvement is mainly due to the increase in the surface area for dissolution, which originates from ...
Dahye Kim, Soeun Jang, Il Won Kim
doaj   +1 more source

Crystallization Behavior of Ceritinib: Characterization and Optimization Strategies

ChemEngineering, 2023
Because of the specific thermodynamic properties of active pharmaceutical ingredients, the process of crystallization often meets implementation challenges in the pharmaceutical industry.
Iva Zokić, Jasna Prlić Kardum
doaj   +1 more source