Results 41 to 50 of about 7,041 (257)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

An improved procedure for synthesis of lenalidomide as an active pharmaceutical ingredient

Results in Chemistry
Lenalidomide is a second-generation immunomodulatory drug widely used in the treatment of multiple myeloma and myelodysplastic syndromes. Market studies indicate that the demand for lenalidomide rising steadily due to the increasing prevalence of ...
Elaheh Ataollahi, Hossein Sadeghpour, Leila Zamani, Soghra Khabnadideh   +3 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Value-added Waste Potential of Wastewater Sludge from Pharmaceutical Industry: A Review

Chemical Engineering Transactions, 2018
Wastewater treatment (WWT) plant treating pharmaceutical processing water produces sludge that may contain residue of the pharmaceutical products.
Siti Norlaila Faeizah Mohd Rudin, Hazrul Adzfar bin Shabri, Zarina Ab Muis, Haslenda Hashim, Wai Shin Ho   +4 more
doaj   +1 more source

Pharmaceutical cocrystal and their role in improving solid state properties of active pharmaceutical ingredients

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2023
Cocrystallization is an emerging approach for improving physico-chemical characteristics of an active pharmaceutical ingredient (API) for instance dissolution rate, solubility, stability in addition to mechanical properties without affecting their ...
Ameera A Radhi, Iman S Jaafar, Noor S Jaafar, Sarah M Faisal   +3 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Upstream pharmaceutical supply chains of 10 high-use pharmaceuticals in the Netherlands: a cohort study

BMJ Open
Objectives To assess the upstream pharmaceutical supply chains of 10 high-use pharmaceuticals to detect vulnerabilities that may increase the risk of medicine shortages.Design Cohort study.Setting Dutch outpatient setting in 2022.Participants A total of ...
Aukje K Mantel-Teeuwisse, Hubert G M Leufkens, Peter A G M De Smet, Doerine J Postma, Kim Notenboom   +4 more
doaj   +1 more source

Composition based on aluminum oxide and polydimethylsiloxane matrix for enhancing drug targeting

Сибирский научный медицинский журнал, 2020
Methodological approaches developed at Research Institute of Clinical and Experimental Lymphology for a number of years allow formulating the importance of embedding active pharmaceutical ingredients (API) in the structure of porous carriers (sorbents ...
M. A. Korolev, L. N. Rachkovskaya, V. I. Konenkov, A. Yu. Letyagin, P. G. Madonov   +4 more
doaj   +1 more source