Results 31 to 40 of about 3,928,328 (244)

Exploratory Study on Active Pharmaceutical Ingredient Manufacturing for Essential Medicines

, 2009
Active Pharmaceutical Ingredients (API) of good quality is core to the manufacturing of effective and safe essential drugs. The price of APIs is the main cost driver for manufacturing. Only a limited number of large
Betsch, Ekkehard, Bumpas, Janet
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Novel Cleaning-in-Place Strategies for Pharmaceutical Hot Melt Extrusion

Pharmaceutics, 2020
To avoid any type of cross-contamination, residue-free production equipment is of utmost importance in the pharmaceutical industry. The equipment cleaning for continuous processes such as hot melt extrusion (HME), which has recently gained popularity in ...
Martin Spoerk, Ioannis Koutsamanis, Josip Matić, Simone Eder, Carolina Patricia Alva Zúñiga, Johannes Poms, Jesús Alberto Afonso Urich, Raymar Andreína Lara García, Klaus Nickisch, Karin Eggenreich, Andreas Berghaus, Kathrin Reusch, Yorick Relle, Johannes Khinast, Amrit Paudel   +14 more
doaj   +1 more source

Data-Driven Prediction of the Formation of Co-Amorphous Systems

Pharmaceutics, 2023
Co-amorphous systems (COAMS) have raised increasing interest in the pharmaceutical industry, since they combine the increased solubility and/or faster dissolution of amorphous forms with the stability of crystalline forms.
Elisabeth Fink, Michael Brunsteiner, Stefan Mitsche, Hartmuth Schröttner, Amrit Paudel, Sarah Zellnitz-Neugebauer   +5 more
doaj   +1 more source

Computer-Aided Retrosynthesis for Greener and Optimal Total Synthesis of a Helicase-primase Inhibitor Active Pharmaceutical Ingredient [PDF]

This study explores the application of computer-aided retrosynthesis (CAR) for developing greener and more efficient synthetic routes for the active pharmaceutical ingredient (API) IM-204, a helicase primase inhibitor with potential against Herpes ...
Renzo, Luisi, Brahim, Benyahia, Rodolfo, Teixeira, Michael , Andresini   +3 more
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

The Analytical method (HPLC) used for identification, assay of triclabendazole, related substances and preservatives used in finished product Tricladem 5, in SC Delos Impex 96 SRL [PDF]

Medicamentul Veterinar, 2012
Because, triclabendazole is an active pharmaceutical ingredient without compendial monography (European Pharmacopoeia, United Stated Pharmacopoeia) in SC Delos Impex ’96 SRL, the API identification, assay, related substances, and, preservatives, assay ...
Maria Neagu, Cristina I. Marinescu, Roxana M. Covaci, Catalina S. Macovei   +3 more
doaj  

Supercritical Fluids and Nanoparticles in Cancer Therapy

Micromachines, 2022
Nanoparticles are widely used in the pharmaceutical industry due to their high surface-to-volume ratio. Among the many techniques used to obtain nanoparticles, those based on supercritical fluids ensure reduced dimensions, narrow particle size ...
Iolanda De Marco
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source