Results 31 to 40 of about 7,041 (257)
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Novel Cleaning-in-Place Strategies for Pharmaceutical Hot Melt Extrusion
Pharmaceutics, 2020 To avoid any type of cross-contamination, residue-free production equipment is of utmost importance in the pharmaceutical industry. The equipment cleaning for continuous processes such as hot melt extrusion (HME), which has recently gained popularity in ...
Martin Spoerk +14 more
doaj +1 more source
Data-Driven Prediction of the Formation of Co-Amorphous Systems
Pharmaceutics, 2023 Co-amorphous systems (COAMS) have raised increasing interest in the pharmaceutical industry, since they combine the increased solubility and/or faster dissolution of amorphous forms with the stability of crystalline forms.
Elisabeth Fink +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The Analytical method (HPLC) used for identification, assay of triclabendazole, related substances and preservatives used in finished product Tricladem 5, in SC Delos Impex 96 SRL [PDF]
Medicamentul Veterinar, 2012 Because, triclabendazole is an active pharmaceutical ingredient without compendial monography (European Pharmacopoeia, United Stated Pharmacopoeia) in SC Delos Impex ’96 SRL, the API identification, assay, related substances, and, preservatives, assay ...
Maria Neagu +3 more
doaj
Supercritical Fluids and Nanoparticles in Cancer Therapy
Micromachines, 2022 Nanoparticles are widely used in the pharmaceutical industry due to their high surface-to-volume ratio. Among the many techniques used to obtain nanoparticles, those based on supercritical fluids ensure reduced dimensions, narrow particle size ...
Iolanda De Marco
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
LCA Tool for Sustainability Evaluations in the Pharmaceutical Industry
Chemical Engineering Transactions, 2012 This article describes an Excel based tool specifically designed to perform the life cycle assessment (LCA) and the sustainability evaluation of pharmaceutical products and/or processes.
T.M. Mata +5 more
doaj +1 more source
Pharmaceutics, 2020 The aim of this work was to assess the impact of an excipient in a pharmaceutical formulation containing candesartan cilexetil over the decomposition of the active pharmaceutical ingredient and to comparatively investigate the kinetics of degradation ...
Valentina Buda +10 more
doaj +1 more source