Results 21 to 30 of about 7,041 (257)

Continuous-Flow Chemistry and Photochemistry for Manufacturing of Active Pharmaceutical Ingredients

Molecules, 2022
An active pharmaceutical ingredient (API) is any substance in a pharmaceutical product that is biologically active. That means the specific molecular entity is capable of achieving a defined biological effect on the target. These ingredients need to meet
Pavlína Horáková, Kamila Kočí
doaj   +1 more source

Database of Active Pharmaceutical Ingredients (APIs) present in the Brazilian Pharmacopeia

Latin American Data in Science, 2022
Active Pharmaceutical Ingredients (APIs) are molecules that can be used for the manufacturing of Drugs. The Brazilian Health Regulatory Agency (Agência Nacional de Vigilância Sanitária) is responsible for the oversight and approval of production and distribution of all drugs in Brazilian territory. Four different databases, including 336 out of the 346
Caio Felipe de Araujo Ribas Cheohen, Bruce Veiga Andriolo, Manuela Leal da Silva   +2 more
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Active Pharmaceutical Ingredient-Ionic Liquids (API-ILs): Nanostructure of the Glassy State Studied by Electron Paramagnetic Resonance Spectroscopy

Molecules, 2022
Active Pharmaceutical Ingredient-Ionic Liquids (API-ILs) draw increasing interest as a particular class of ILs that possess unusual physicochemical properties along with simultaneous potentials for pharmaceutical applications.
Olga D. Bakulina, Mikhail Yu. Ivanov, Dmitriy V. Alimov, Sergey A. Prikhod’ko, Nicolay Yu. Adonin, Matvey V. Fedin   +5 more
doaj   +1 more source

A Sourcing Strategy for Active Pharmaceutical Ingredients (APIs)

CHIMIA, 1998
We describe the development over the past decade of a sourcing strategy within the Roche group for active pharmaceutical ingredients and the intermediates used in their manufacture. The roles of certain production sites have been modified in the light of this strategy.
George M. Clarke, K. Peter Schnurrenberger, Bernhard Scholl   +2 more
openaire   +3 more sources

Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach

Pharmaceutics, 2020
In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter
Xavier Buol, Koen Robeyns, Camila Caro Garrido, Nikolay Tumanov, Laurent Collard, Johan Wouters, Tom Leyssens   +6 more
doaj   +1 more source

Dissolution from Ethylene Vinyl Acetate Copolymer Long-Acting Implants: Effect of Model Active Ingredient Size and Shape

Pharmaceutics, 2022
In recent pharmaceutical applications, an active pharmaceutical ingredient (API) can be mixed with a polymer material to yield a composite long-acting drug-delivery device. These devices boast higher patient compliance, localized drug delivery, and lower
Anne M. Gohn, Amy Nolte, Ethan Ravotti, Seth P. Forster, Morgan Giles, Nathan Rudd, Gamini Mendis   +6 more
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Interpretation of Guidelines for Occupational Hazard Assessment and Control of Active Pharmaceutical Ingredient in the Pharmaceutical Industry (T/WSJD60—2024)

环境与职业医学
The Guidelines for Occupational Hazard Assessment and Control of Active Pharmaceutical Ingredient in the Pharmaceutical Industry (T/WSJD 60—2024) is the first guiding standard in the field of health in China that focuses on occupational health protection
Ying TANG, Jian CHEN, Tao LI, Huifang YAN, Yongqing CHEN, Yi XU, Yong NING, Man YU, Chenyi TAO, Xia ZHANG   +9 more
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Deep Eutectic Solvents as Active Pharmaceutical Ingredient Delivery Systems in the Treatment of Metabolic Related Diseases

Frontiers in Pharmacology, 2021
Metabolic related diseases such as cancer, diabetes mellitus and atherosclerosis are major challenges for human health and safety worldwide due to their associations with high morbidity and mortality.
Cixin Huang, Cixin Huang, Cixin Huang, Xiunian Chen, Xiunian Chen, Xiunian Chen, Chao Wei, Chao Wei, Hongwei Wang, Hongwei Wang, Hua Gao, Hua Gao, Hua Gao   +12 more
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Cost of goods sold analysis and recommendations to reduce costs of co-packaged mifepristone–misoprostol for medical abortion

Reproductive Health, 2020
Objective Understanding the price components of the mifepristone/misoprostol (combi-pack) for medical abortion to improve access is critical for identifying strategies to reduce product costs for quality-assured formulations and expanding its ...
Lester Chinery, Chadia Allaouidine, Alessandra Tomazzini, Melanie Larson, A. Metin Gülmezoglu   +4 more
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Improving stereoselectivity of phosphotriesterase (PTE) for kinetic resolution of chiral phosphates

Frontiers in Bioengineering and Biotechnology
Specific stereoisomer is paramount as it is vital for optimizing drug efficacy and safety. The quest for the isolation of desired stereoisomer of active pharmaceutical ingredients or key intermediates drives innovation in drug synthetic and biocatalytic ...
Nongluck Jaito, Suthathip Phetlum, Titiporn Saeoung, Thanat Tiyasakulchai, Nitipol Srimongkolpithak, Tanaporn Uengwetwanit   +5 more
doaj   +1 more source