Results 21 to 30 of about 4,119,069 (249)

Continuous-Flow Chemistry and Photochemistry for Manufacturing of Active Pharmaceutical Ingredients

Molecules, 2022
An active pharmaceutical ingredient (API) is any substance in a pharmaceutical product that is biologically active. That means the specific molecular entity is capable of achieving a defined biological effect on the target. These ingredients need to meet
Pavlína Horáková, Kamila Kočí
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Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach

Pharmaceutics, 2020
In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter
Xavier Buol, Koen Robeyns, Camila Caro Garrido, Nikolay Tumanov, Laurent Collard, Johan Wouters, Tom Leyssens   +6 more
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Dissolution from Ethylene Vinyl Acetate Copolymer Long-Acting Implants: Effect of Model Active Ingredient Size and Shape

Pharmaceutics, 2022
In recent pharmaceutical applications, an active pharmaceutical ingredient (API) can be mixed with a polymer material to yield a composite long-acting drug-delivery device. These devices boast higher patient compliance, localized drug delivery, and lower
Anne M. Gohn, Amy Nolte, Ethan Ravotti, Seth P. Forster, Morgan Giles, Nathan Rudd, Gamini Mendis   +6 more
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Interpretation of Guidelines for Occupational Hazard Assessment and Control of Active Pharmaceutical Ingredient in the Pharmaceutical Industry (T/WSJD60—2024)

环境与职业医学
The Guidelines for Occupational Hazard Assessment and Control of Active Pharmaceutical Ingredient in the Pharmaceutical Industry (T/WSJD 60—2024) is the first guiding standard in the field of health in China that focuses on occupational health protection
Ying TANG, Jian CHEN, Tao LI, Huifang YAN, Yongqing CHEN, Yi XU, Yong NING, Man YU, Chenyi TAO, Xia ZHANG   +9 more
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Deep Eutectic Solvents as Active Pharmaceutical Ingredient Delivery Systems in the Treatment of Metabolic Related Diseases

Frontiers in Pharmacology, 2021
Metabolic related diseases such as cancer, diabetes mellitus and atherosclerosis are major challenges for human health and safety worldwide due to their associations with high morbidity and mortality.
Cixin Huang, Cixin Huang, Cixin Huang, Xiunian Chen, Xiunian Chen, Xiunian Chen, Chao Wei, Chao Wei, Hongwei Wang, Hongwei Wang, Hua Gao, Hua Gao, Hua Gao   +12 more
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Characterization of the conglomerate form of acetyl-dl-leucine by thermal analysis and solubility measurements [PDF]

, 2012
Starting from a mixture of enantiomers in solution, crystallization can generate different types of crystals. In order to determine which type of crystal is obtained in the case of acetylleucine, an active pharmaceutical ingredient (API), analytical ...
B. Biscans, Pena, Richard, S. Teychené, Estime, Nicolas, Biscans, Béatrice, R. Pena, N. Estime, Teychené, Sébastien, Autret, Jean Marie, J.M. Autret   +9 more
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Lipase enzymes for sustainable synthesis of chiral active pharmaceutical ingredients (API) and key starting materials [PDF]

Biocatalysis is considered as a green and sustainable process for synthesis of chiral organic building blocks and active pharmaceutical ingredients (API).
Sharada Prasanna, Swain, Moumita, Khanra
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Determination of active pharmaceutical ingredient – chloropyramine in dragées [PDF]

, 2015
Chloropyramine is a first generation antihistamine drug approved in some Eastern European countries for the treatment of allergic conjunctivitis, allergic rhinitis, bronchial asthma, and other allergic conditions. Chloropyramine is known as a competitive
Gjorgjeska, Biljana, Kostik, Vesna, Petkovska, Sofija   +2 more
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Cost of goods sold analysis and recommendations to reduce costs of co-packaged mifepristone–misoprostol for medical abortion

Reproductive Health, 2020
Objective Understanding the price components of the mifepristone/misoprostol (combi-pack) for medical abortion to improve access is critical for identifying strategies to reduce product costs for quality-assured formulations and expanding its ...
Lester Chinery, Chadia Allaouidine, Alessandra Tomazzini, Melanie Larson, A. Metin Gülmezoglu   +4 more
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Improving stereoselectivity of phosphotriesterase (PTE) for kinetic resolution of chiral phosphates

Frontiers in Bioengineering and Biotechnology
Specific stereoisomer is paramount as it is vital for optimizing drug efficacy and safety. The quest for the isolation of desired stereoisomer of active pharmaceutical ingredients or key intermediates drives innovation in drug synthetic and biocatalytic ...
Nongluck Jaito, Suthathip Phetlum, Titiporn Saeoung, Thanat Tiyasakulchai, Nitipol Srimongkolpithak, Tanaporn Uengwetwanit   +5 more
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