Results 91 to 100 of about 3,928,328 (244)

Ibuprofen-Amino Acids Co-Crystal Screening Via Co-Grinding Methods

MATEC Web of Conferences, 2016
The importance of pharmaceutical co-crystals now has been recognized in order to improve the research and development in pharmaceutical industries. Low solubility of active pharmaceutical ingredient (API) has led to the growth of new pharmaceutical co ...
Othman Muhamad Fitri, Jamburi Norasikin, Anuar Nornizar, Abd. Rahim Syarifah, Rohalim Nurul Hazwani   +4 more
doaj   +1 more source

Aza‐Büchner–Curtius–Schlotterbeck Reaction Enables Selective Construction of Quaternary Carbon Centers

Angewandte Chemie International Edition, EarlyView.
We introduce the Aza‐Büchner–Curtius–Schlotterbeck (ABCS) reaction: A mild, catalyst‐free method for homologating aryl imines. Diverging from the traditional BCS mechanism, the diazo intermediate undergoes selective C─C insertion to form an all‐carbon quaternary center.
Simon O. Angerer, Vincent George, Aryaman Pattanik, Gaia Carpentiero, Tereza Morcinková, Julia Rehbein, Burkhard König   +6 more
wiley   +1 more source

Interactions and incompatibilities of pharmaceutical excipients with active pharmaceutical ingredients: a comprehensive review [PDF]

Studies of active drug/excipient compatibility represent an important phase in the preformulation stage of the development of all dosage forms. The potential physical and chemical interactions between drugs and excipients can affect the chemical nature ...
Sandip B. Bharate, Amrita N. Bajaj, Sonali S. Bharate   +2 more
core   +1 more source

Co-Crystal Screening of Diclofenac

Pharmaceutics, 2011
In the pharmaceutical industry, co-crystals are becoming increasingly valuable as crystalline solids that can offer altered/improved physical properties of an active pharmaceutical ingredient (API) without changing its chemical identity or biological ...
John Desper, Christer B. Aakeröy, Angela B. Grommet   +2 more
doaj   +1 more source

Context‐centric proactive information delivery for Knowledge Work support: Opportunities, challenges, and directions. An Annual Review of Information Science and Technology (ARIST) paper

Journal of the Association for Information Science and Technology, EarlyView.
Abstract Context‐centric proactive information delivery (PID) is a relatively underexplored domain within recommender systems (RS) aimed at enhancing Knowledge Workers' productivity by proactively providing relevant information during digital tasks.
Mahta Bakhshizadeh, Christian Jilek, Markus Schröder, Heiko Maus, Andreas Dengel   +4 more
wiley   +1 more source

The impact of medication shortages on paediatric care: A retrospective impact analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Medication shortages are a growing global concern, with potentially greater consequences in paediatric patients because of the limited availability of safe, evidence‐based and appropriately formulated medication. This study aimed to evaluate the impact of medication shortages on paediatric patients by assessing the suitability and safety of ...
Maaike Johanna Rutten ‐ van Kranenburg, Laurens Christiaan van Rijn, Elisabeth Johanna Ruijgrok, Sinno Henricus Paulus Simons, Brigitta Carolina Maria Witjes, Jan‐Dietert Christoffer Brugma, Robert Bernard Flint   +6 more
wiley   +1 more source

Safety outcomes of antidiabetic medications: A comprehensive review of the EU summaries of product characteristics and international clinical practice guidelines

British Journal of Clinical Pharmacology, EarlyView.
Aims Information on the safety profile of antidiabetic medications is essential for informed treatment decisions in type 2 diabetes mellitus. Although this information is available in regulatory documents of individual drugs, a comprehensive overview across all approved antidiabetics is lacking.
David Liang, Daniala L. Weir, Safana Thevasahayam, Vera H. M. Deneer, Arno Siebes, Helga Gardarsdottir   +5 more
wiley   +1 more source

IMPACT OF ACTIVE PHARMACEUTICAL INGREDIENT (API) SCARCITY IN PHARMACEUTICAL SECTORS AMIDST COVID-19 PANDEMIC [PDF]

, 2020
The novel coronavirus disease 2019 (COVID-19) was characterized as a global pandemic by the World Health Organization (WHO) on March 11, 2020. The present pandemic has caused an intolerable impact on the health structure as well as the pharmaceutical ...
MALLIK, SANTANU, SAHA, ARPAN
core   +1 more source

Machine Learning‐Based PAT Tool for Real‐Time Residual Moisture Monitoring in Lyophilized Biopharmaceuticals Using NIR Spectroscopy

Biotechnology and Bioengineering, EarlyView.
ABSTRACT There is a growing demand in the pharmaceutical industry to optimize analytical methodologies, reducing time and resource consumption while ensuring rapid process development and cost‐efficient manufacturing. Indeed, Food and Drug Administration (FDA) introduced the Process Analytical Technology (PAT) as an initiative enabling manufacturers to
Samuele Fiorenza, Mariapia D'Urso, Ambra Massei, Nunzia Falco, Davide Fissore, Enza Torino   +5 more
wiley   +1 more source

Cell culture media: An active pharmaceutical ingredient or ancillary material?

, 2018
Cell culture media are used to manufacture cell-based therapies. A number of essential materials are involved in the manufacture of cellbased therapies, including the active pharmaceutical ingredient (API), ancillary materials (AMs), and raw materials ...
Alturkistani, A, Meinert, Edward, Carter, Alison, Brindley, David   +3 more
core