Results 161 to 170 of about 3,928,328 (244)

Modification patents across multiple NDAs in pharmaceutical protections. [PDF]

Health Aff Sch
Feldman R, Alsaffar R, Sakib T.
europepmc   +1 more source

Exposure to Structurally Related Organophosphate Esters Elicits Distinct Metabolomic Perturbations in Daphnia magna

Environmental Toxicology, EarlyView.
ABSTRACT Organophosphate esters (OPEs) are found ubiquitously in the environment and exposure to these chemicals has induced behavioral, developmental, and morphological impairments in several model organisms. Yet there is still a lack of understanding of how sub‐lethal exposure disrupts organism function at the molecular‐level, especially for Daphnia ...
Salwa Hajir, Sanam Yousifie, Karl J. Jobst, André J. Simpson, Myrna J. Simpson   +4 more
wiley   +1 more source

Taurine-based Active Pharmaceutical Ingredient Ionic Liquids Modulate the Perifollicular Microenvironment for Androgenic Alopecia Treatment. [PDF]

Adv Healthc Mater
Yang L, Wang Y, Lei L, He B, Chen Y, Cao J.   +5 more
europepmc   +1 more source

Route‐Dependent Toxicity and Ecological Selectivity of Melaleuca alternifolia Essential Oil in Apis mellifera Linnaeus, 1758 (Hymenoptera: Apidae)

Environmental Toxicology, EarlyView.
ABSTRACT The intensification of agricultural practices has led to an increase in the use of insecticides, raising concerns about the exposure of non‐target organisms, particularly pollinators. In this context, plant‐derived essential oils have been proposed as environmentally friendlier alternatives due to their low persistence; however, their ...
Silvane Zancanaro de Oliveira, Elizabete Artus Berte, Juliana Marceli Hofma Lopes, Cristiane Lurdes Paloschi, Edgar de Souza Vismara, Vitória Alves Pereira, Fernanda Raulino Domanski, Natália Ramos Mertz, Fabiana Martins Costa, Everton Ricardi da Silva Lozano, Jhenneffer Tainara Zancanaro Ghizzi, Michele Potrich   +11 more
wiley   +1 more source

Commercial Product Based on Metarhizium Anisopliae Affects Survival, Midgut Morphology, and Behavior in the Stingless Bee Scaptotrigona depilis (Hymenoptera: Apidae)

Environmental Toxicology, EarlyView.
ABSTRACT Brazilian social stingless bees are important pollinators and producers of honey, wax, royal jelly, propolis, and other products. These species are experiencing a population decline, attributed to different factors, such as the excessive use of pesticides.
Andressa Santoro, Daiani Rodrigues Moreira, Talita Aparecida Tódora Santana, Wingly Santos Beltrame, Nathalia Rodrigues da Silva de Carvalho, Breno Gabriel da Silva, Gustavo Henrique de Souza, Livia Bracht, Adriana Aparecida Sinópolis Gigliolli, Maria Claudia Colla Ruvolo Takasusuki   +9 more
wiley   +1 more source

No gain from pain: Lack of nociceptor activation suggests no adaptation for defence in the evolution of European viper venoms

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Snake venoms show variability in composition at all taxonomic levels, both within and between species, and the selective pressures underlying this variation have long been debated.
Bálint Üveges, Samuel D. Robinson, Vanessa Schendel, Edvárd Mizsei, Ana Ćuriċ, Maria Dimaki, Vincenzo Ferri, Silviu Petrovan, Andrea V. Pozzi, Tihomir Radonjiċ, Tibor Sos, Jeffrey W. Streicher, Alexandru Strugariu, Emina Šunje, Ștefan Zamfirescu, Oleksandr Zinenko, Irina Vetter, Wolfgang Wüster   +17 more
wiley   +1 more source

Preformulation Studies and Rational Design of an Ointment Containing a Postbiotic Metabolite of Procyanidins for Topical Use. [PDF]

Pharmaceutics
Todryk T, Budnicka M, Pajchel L, Kierońska H, Dawidowski M, Stępień KA, Giebułtowicz J, Granica S, Kolmas J, Piwowarski JP.   +9 more
europepmc   +1 more source

Human‐supervised LLM triage of pig butchering complaints: A validation study of multi‐model identifier extraction

Journal of Forensic Sciences, EarlyView.
Abstract Digital forensic investigations increasingly process unstructured cryptocurrency‐fraud complaints at intake while preserving analyst oversight before evidentiary or downstream investigative use. This validation study evaluates whether human‐supervised multi‐model LLM extraction can recover triage‐relevant identifiers from California DFPI pig ...
Sanghyeob Ko, Jumi Kim, Jin Young Jang, Gibum Kim   +3 more
wiley   +1 more source

Distributed Manufacturing, Foreign Establishments, and Why the FDA's New Proposed Rule Matters to Clinical Pharmacology. [PDF]

Clin Pharmacol Drug Dev
Issa AM.
europepmc   +1 more source

The law of AI knowledge distillation

American Business Law Journal, EarlyView.
Abstract Knowledge distillation—the practice of training a compact student model on the outputs of a larger teacher model—has emerged as the fastest‐growing technique for replicating and disseminating frontier artificial intelligence (AI) capabilities.
Taorui Guan
wiley   +1 more source