Results 181 to 190 of about 4,119,069 (249)

Genetics‐Informed Pharmacological Intervention in Gestational Diabetes Mellitus: Current Therapeutic Alignment, Emerging Targets and a Translational Roadmap

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Gestational diabetes mellitus (GDM) complicates roughly one in seven pregnancies and predicts later maternal type 2 diabetes mellitus (T2DM). Yet its pharmacological management still rests on a handful of agents (insulin, metformin and glibenclamide), none of them selected on the basis of the disease's molecular genetics.
Wael Osman
wiley   +1 more source

Emerging Technologies in Granulation: Process Analytical Technologies and Modeling Approaches in Pharmaceutical Development and Manufacturing. [PDF]

Pharmaceutics
Pentsis P, Chountoulesi M, Christodoulou E, Pippa N.   +3 more
europepmc   +1 more source

GLP‐1 Receptor Agonist Therapy Is Associated With Lower Risk of Lower Extremity Amputation in Adults With Type 2 Diabetes and Foot Ulcer Without Coded Peripheral Arterial Disease: A Hypothesis‐Generating Real‐World Cohort Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To compare lower extremity amputation (LEA) risk in adults with Type 2 diabetes and diabetic foot ulcer (DFU) treated with glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) versus other glucose‐lowering therapy, and to test whether coded peripheral arterial disease (PAD) modifies this association and replicates across comparator ...
Hani Robinson, Mustafa Yassin, Dror Robinson, Mohamad Eisa, Waseem Abu Rashed, Feras Qawasmi, Assil Mahamid, Hamza Murad, Muhammad Khatib   +8 more
wiley   +1 more source

Impurities and Potential Immunogenicity Associated With Follow-on and Compounded Glucagon-like Peptide-1 Receptor Agonists. [PDF]

Pharm Res
Kopp KL, Lamberth K, Schelde O, Øgendahl AK, Wojcieszek M, Mogensen JE, Ramírez-Andersen HS, Schneider CL, Staby A, Hach M.   +9 more
europepmc   +1 more source

Real‐World Treatment Patterns and Weight Outcomes Before and After a Tirzepatide Price Increase in Over One Million Self‐Paying UK Adults With Overweight or Obesity

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Glucagon‐like peptide‐1 (GLP‐1) receptor agonist‐based medicines are highly effective treatments for overweight and obesity, but population‐scale real‐world evidence remains limited, particularly in self‐funded settings where treatment choice may be influenced by relative price.
Sophie Dix, Anna Mulligan, Mattia Ficarelli, Edward Brooke, Onayomi Rosenior‐Patten, Simon Chen, Catriona Maybury, Benjamin D. Bray   +7 more
wiley   +1 more source

Oseltamivir-Based Organic Salts and Ionic Liquids: Physicochemical Properties, Cytotoxicity, and Neuraminidase Inhibition. [PDF]

Pharmaceutics
Madeira DA, Correia V, Santos L, Rebelo-de-Andrade H, Branco LC.   +4 more
europepmc   +1 more source

Autophagy Regulates Foxo1 Protein Abundance to Control Hepatic Glucose Production in Glucagon Signalling

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim During fasting, the liver undergoes coordinated metabolic adaptations to maintain systemic energy homeostasis. These adaptations are driven in part by glucagon, which promotes hepatic glucose production (HGP) and fatty acid oxidation (FAO) through mechanisms involving the transcription factor Foxo1.
Zheng Shen, Wanbao Yang, Quan Pan, Wen Jiang, Jeffrey Guo, Yuxiang Sun, Nicolaas Deutz, Bhimanagouda S. Patil, Pingwei Li, Shaodong Guo   +9 more
wiley   +1 more source

Pharmaceutical quality of artemether-lumefantrine in Rwanda's public health supply chain: a cross-sectional post-market surveillance study. [PDF]

Malar J
Rutayisire R, Uwimana A, Rujeni N, Ndoricyimpaye EL, Ntirenganya L, Caillet C, Dhorda M, Mutesa L.   +7 more
europepmc   +1 more source

Obesity and the Development of Cardiometabolic Multimorbidity: A Cross‐Lagged Panel Network Analysis of Three National Chinese Cohorts

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To explore longitudinal and bidirectional associations between obesity and cardiometabolic diseases (CMDs) using a cross‐lagged panel network (CLPN) framework in three nationally representative Chinese cohorts. Materials and Methods We analysed participants aged 45 years and older from CHARLS (2011–2015; n = 12 491), CHNS (2004–2015; n ...
Zeping Fang, Jinli Liu, Lei Zhang
wiley   +1 more source

Amylin Receptor Signalling in the Laterodorsal Tegmental Nucleus Controls Food Intake Through Projections to the Ventral Tegmental Area

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background The role of amylin signalling in energy balance control has been understudied in calcitonin receptor (CTR) expressing nuclei such as the mesopontine laterodorsal tegmental nucleus (LDTg). Our lab has shown that LDTg amylin signalling reduces feeding and body weight, but the neuronal phenotype and downstream targets of LDTgCTR cells ...
Marcos J. Sanchez Navarro, Carlie Zhang, Samantha M. Fortin, Matthew R. Hayes   +3 more
wiley   +1 more source