Results 201 to 210 of about 4,119,069 (249)

Changes in Muscle Strength Following Semaglutide Treatment in Adults: A Systematic Review With Meta‐Analysis of Handgrip Strength

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To systematically review and quantitatively synthesize within‐group changes in skeletal muscle strength following semaglutide treatment in adults. Materials and Methods This PRISMA 2020 systematic review was registered in PROSPERO (CRD420251185935).
Luís Guilherme Machado, Pedro Henrique Siedschlag Schmidt, Guido Tasca Petroski, Geraldo Lucas Lopes Costa, Letícia Vieira dos Santos Ribeiro, João Victor Ramos Da Cruz, Graziela De Luca Canto, Alexandre Hohl, Marcelo Fernando Ronsoni, Simone van de Sande‐Lee   +9 more
wiley   +1 more source

Safety, Tolerability, Pharmacokinetics and Exploratory Pharmacodynamics of Melanin‐Concentrating Hormone Receptor‐1 Antagonist RGH‐706 in Healthy and Overweight or Obese Men

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim This Phase 1 program evaluated the safety, tolerability, pharmacokinetics and exploratory pharmacodynamics of the novel melanin‐concentrating hormone receptor‐1 antagonist RGH‐706. Methods Study A was a first‐in‐man, randomized trial comprising a double‐blind, placebo‐controlled single‐ascending‐dose part (0.1–162.5 mg) and a two‐way ...
Thomas Brevig, Borbála Szepes, Zsófia Borbála Dombi, Gabriella Magyar, Zoltán Juhász, Margit Kapás, Éva Cseh, Zsuzsa Hegedűs, Tibor Farkas, Zsuzsanna Kiss, Balázs Szatmári   +10 more
wiley   +1 more source

Preformulation Studies and Rational Design of an Ointment Containing a Postbiotic Metabolite of Procyanidins for Topical Use. [PDF]

Pharmaceutics
Todryk T, Budnicka M, Pajchel L, Kierońska H, Dawidowski M, Stępień KA, Giebułtowicz J, Granica S, Kolmas J, Piwowarski JP.   +9 more
europepmc   +1 more source

Patient‐Reported Outcomes Following Initiation or Simplification of Treatment With iGlarLixi in Adults With Type 2 Diabetes: A Narrative Review

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Given the significant burden that diabetes self‐management poses, it is important to assess patient‐reported outcomes (PROs) for Type 2 diabetes (T2D) treatments in clinical trials and real‐world studies. Complex insulin regimens are associated with increased risk of hypoglycaemia and body weight gain, which could negatively ...
Francesco Giorgino, Martin Haluzík, Agustina Alvarez, Felipe Lauand, Valérie Corp dit Genti, Samir H. Assaad‐Khalil, Hemant Thacker, Tomasz Klupa, Oguzhan Deyneli, Julio Rosenstock   +9 more
wiley   +1 more source

Influence of Core and Membrane Composition on Drug Release from MCC/Isomalt-Based Matrix Pellets in Biorelevant Osmolarity Media. [PDF]

Pharmaceutics
Fleck C, Aghrbi I, Vlahovic K, Erdő F, Laki AJ, Kállai-Szabó N, Antal I, Lengyel M.   +7 more
europepmc   +1 more source

Efficacy and Feasibility of Just‐in‐Time Nudging in Reducing Evening Snacking Measured by Continuous Glucose Monitoring in Adults With Type 2 Diabetes: A Micro‐Randomized Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims This study aimed to determine whether in people with Type 2 diabetes mellitus (T2DM), a digital nudge delivered by a smartphone app soon after dinner reduces subsequent snacking events as measured by continuous glucose monitoring (CGM). Methods Participants: Adults with T2DM, managed with diet or stable oral antidiabetic medication for at
Lijun Zhao, Niranjan Bidargaddi, Andrew Vakulin, Wenhao Li, Natalie Luscombe‐Marsh, Fiona Benton, Robert Adams, Eva Kemps, Andrew D. Vincent, Leonie K. Heilbronn, Gary A. Wittert   +10 more
wiley   +1 more source

Nucleic Acid Nanoparticles Redefine Traditional Regulatory Terminology: The Blurred Line between Active Pharmaceutical Ingredients and Excipients. [PDF]

ACS Nano Med
Kozlov S, Panigaj M, Rebolledo L, Bhaskaran H, Afonin KA.   +4 more
europepmc   +1 more source

Incorporation of Carob Into a High‐Fat Meal Influences Subjective Satiety, Ghrelin and PYY Regulation

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Dietary components that influence appetite‐related hormones and subjective satiety may help regulate food intake. Aqueous carob (Ceratonia siliqua L.) preparations may have a role in postprandial appetite regulation. Aims To investigate the effects of an aqueous carob preparation incorporated into a high‐fat meal on postprandial ...
Charalampia Amerikanou, Stamatia‐Angeliki Kleftaki, Chara Tzavara, Aikaterini Vourtsi, Aristea Gioxari, Andriana C. Kaliora   +5 more
wiley   +1 more source

Distributed Manufacturing, Foreign Establishments, and Why the FDA's New Proposed Rule Matters to Clinical Pharmacology. [PDF]

Clin Pharmacol Drug Dev
Issa AM.
europepmc   +1 more source