Results 181 to 190 of about 3,356,214 (292)

THC-net: an attention-based deep learning model for chromatin compartment prediction from histone modifications. [PDF]

BMC Bioinformatics
Wang J, Meng X, Shen J, Luo J.
europepmc   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Calibrated and explainable multiparametric MRI radiomics for differentiating tumor positive disease from treatment-related changes in glioblastoma. [PDF]

Front Oncol
Christodoulou RC, Vamvouras G, Esmeraldo MA, Papageorgiou PS, Vassiliou E, Solomou EE, Papageorgiou SG, Georgiou MF.   +7 more
europepmc   +1 more source

Sustainable Fabrication of Tailored Bone Substitutes: From High‐Throughput Scaffold Manufacturing, Scaled‐Up HMSC Expansion to Dynamic Cultivation in a Perfusion Bioreactor

Advanced Science, EarlyView.
ABSTRACT The demand for off‐the‐shelf biocompatible bone substitutes has driven the development of numerous independent in vitro technologies to generate products resembling physiological tissues. Due to technical challenges and overly simplified cultivation approaches/niches, the end‐products are often uniformly shaped and inferior to native bone ...
Franziska Braun, Anna Paříková, Sandra Rother, Martin Kantor, Salman Muhammad Ilyas, Ricardo Bernhardt, Pavel Ndjawa Yomi, Jaromír Havlica, Revathi Appali, Benjamin Kruppke, Poh Soo Lee   +10 more
wiley   +1 more source

Hearing loss associated with CDC42 in mice and humans (Takenouchi-Kosaki syndrome): CDC42 and RHOQ synergistically function in cochlear hair cells. [PDF]

J Biol Chem
Ueyama T, Ganaha A, Kurasawa S, Mohri H, Nakamura T, Morioka S, Kawama F, Kitayama S, Oishi N, Kaname T, Tabuchi K, Kosaki K, Takenouchi T, Sakaguchi H.   +13 more
europepmc   +1 more source

Performance–Complexity Trade‐Offs in Battery Lifetime Prediction with Task‐Aware Transformers

Advanced Science, EarlyView.
FAST‐BatPro integrates convolutional feature extraction, flash Attention, and sparse attention for efficient battery lifetime prediction. Using limited early‐cycle data across multiple chemistries and operating conditions, it achieves robust accuracy while reducing inference latency, computational cost, and energy consumption.
Jingyuan Zhao, Misheng Cai, Zhenghong Wang, Yan Wang, Yuqi Li, Bo Dong, Hewu Wang, Andrew F. Burke, Simona Onori, Stephen J. Harris   +9 more
wiley   +1 more source

Sustainable Materials Design With Multi‐Modal Artificial Intelligence

Advanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu, Tianshuo Wei, Yan Ge, Bo Peng, Yue Li, Maolin Wang, Peng Wen, Chao Yang, Ye Wei   +8 more
wiley   +1 more source

Iron-Modified Biochar Reduces Phosphorus Leaching and Maintains Microbial Network Complexity in Acidic Soils Under Simulated Intense Rainfall. [PDF]

Microorganisms
Luo Y, Liu Z, Zhang Y, Cui C, Wang G, Dong L, Wan S.   +6 more
europepmc   +1 more source

Ferroelectric Devices for In‐Memory and In‐Sensor Computing

Advanced Science, EarlyView.
Inspired by biological systems, in‐memory and in‐sensor computing overcome von Neumann bottlenecks. Ferroelectric devices can mimic synaptic functions and sense stimuli like light or force, therefore are ideal for these paradigms. This review introduces the ferroelectric devices applied for in‐memory and in‐sensor computing, covering their structures ...
Hong Fang, Ronghuan Xie, Qiang Cao, Shishen Yan, Xiaolin Wang, Limei Zheng   +5 more
wiley   +1 more source

Short-term thinning alters labile soil phosphorus fractions and is associated with microbial alpha diversity and phosphatase activity in subtropical conifer plantations. [PDF]

Front Plant Sci
Yang B, Li L, Luo K, Li S, Liu Y, Lin K, Luo L, Xu X, Tao L, Liu Y.   +9 more
europepmc   +1 more source